Rapid Determination of Finasteride in Human Plasma by UPLC-MS/MS and Its Application to Clinical Pharmacokinetic Study

    April 2010 in “ Journal of Chromatography B ”
    Panagiotis L. Kastritis, Hae Young Lee, Mi-sun Lim … Young-Ran Yoon
    Studysummary This study describes a validated UPLC-MS/MS method for quantifying finasteride in human plasma, demonstrating higher specificity, improved resolution, increased sensitivity, and faster analysis times compared to conventional HPLC-MS/MS methods.
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    Research cited in this study 11

    1. A Rapid, Simple, Specific Liquid Chromatographic–Electrospray Mass Spectrometry Method for the Determination of Finasteride in Human Plasma and Its Application to Pharmacokinetic Study Journal of Pharmaceutical and Biomedical Analysis · 2006
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    6. Finasteride Drugs · 1999
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    8. Finasteride in Biological Fluids: Extraction and Separation by a Graphitized Carbon Black Cartridge and Quantification by High-Performance Liquid Chromatography Journal of Chromatography B: Biomedical Sciences and Applications · 1997
    9. High-Performance Liquid Chromatographic Determination of Finasteride in Human Plasma Using Direct Injection with Column Switching Journal of Chromatography B: Biomedical Sciences and Applications · 1996
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    11. Picogram Determination of Finasteride in Human Plasma and Semen by High-Performance Liquid Chromatography with Atmospheric-Pressure Chemical-Ionization Tandem Mass Spectrometry Journal of Chromatography B: Biomedical Sciences and Applications · 1994