The Impact of COVID-19 on the Menstrual Cycle: A General Perspective

    March 2023 in “ Brazilian Journal of Health Review ”
    Anna Caroline Loyola Sampaio, Jéssica dos Santos Coelho, Paloma Luna Maranhão Conrado, Valda Lúcia Moreira Luna, Pauliana Valeria Machado Galvão, George Alessandro Maranhão Conrado
    TLDR The combination tablet of finasteride and doxazosin works the same as taking each drug separately.
    The study aimed to evaluate the pharmacokinetic profile and bioequivalence of a fixed combination tablet containing finasteride (5 mg) and doxazosin (2 mg) compared to the individual administration of these drugs. Conducted as a randomized, crossover study with 30 subjects, the results showed no significant differences in the pharmacokinetic parameters (AUC0-72h, AUC0-∞, and Cmax) between the combination tablet and the single agents. The mean ratios of AUC0-72h/AUC0-∞ for finasteride and doxazosin were nearly 100%, indicating adequate sampling time and confirming bioequivalence. This suggests that the combination tablet does not alter the pharmacokinetics of the individual drugs, supporting its use in clinical practice.
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