Discontinuation of Alpha-Blockade After Initial Treatment With Finasteride and Doxazosin for Bladder Outlet Obstruction

    February 2001 in “ Urologia Internationalis ”
    Kelly Baldwin, Phillip C. Ginsberg, Richard C. Harkaway
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    TLDR Stopping alpha-blocker medication after 6-9 months is safe and effective for most patients with bladder outlet obstruction.
    A study examined the effectiveness of discontinuing alpha-blocker medication after initial treatment with finasteride and doxazosin for bladder outlet obstruction caused by benign prostatic hyperplasia. The study found that it is safe and effective to discontinue alpha-blockade after six to nine months of combination therapy. Most patients did not experience any changes in their symptoms, but some reported worsening symptoms after discontinuation. The study supports previous research on the effectiveness of finasteride in treating benign prostatic hyperplasia. However, more research is needed to determine the effectiveness of these treatments for patients with different prostate sizes and over longer periods of time.
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