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GlossaryUltra-Performance Liquid Chromatography Tandem Mass Spectrometry (UPLC-MS MS)

advanced technique for separating and identifying compounds in samples

Ultra-Performance Liquid Chromatography Tandem Mass Spectrometry (UPLC-MS/MS) is an advanced analytical technique used to separate, identify, and quantify compounds in a sample. UPLC enhances the resolution and speed of liquid chromatography, while MS/MS provides highly sensitive and specific detection by breaking down molecules into fragments and analyzing their mass. This method is widely used in fields like pharmacology, biochemistry, and environmental science for precise and accurate analysis of complex mixtures.

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research Rapid Determination of Finasteride in Human Plasma by UPLC-MS/MS and Its Application to Clinical Pharmacokinetic Study

18 citations , April 2010 in “Journal of Chromatography B”

New method measures finasteride in blood quickly and accurately.

research Simultaneous Determination of 30 Hormones Illegally Added to Anti-Aging Functional Foods Using UPLC-MS/MS Coupled with SPE Clean-Up

6 citations , September 2014 in “Food Additives & Contaminants: Part A”

New method effectively detects illegal hormones in anti-aging foods.

UPLC-MS/MS Method for the Simultaneous Quantification of Caffeine and Illicit Psychoactive Drugs in Hair Using a Single-Step High-Speed Grinding Extraction – Insights into a Cut-Off Value for Caffeine Abuse

research UPLC-MS/MS Method for the Simultaneous Quantification of Caffeine and Illicit Psychoactive Drugs in Hair Using a Single-Step High-Speed Grinding Extraction – Insights into a Cut-Off Value for Caffeine Abuse

4 citations , February 2022 in “Journal of Pharmaceutical and Biomedical Analysis”

The conclusion is that a new method can measure caffeine and drugs in hair, finding caffeine abusers have 70 times more caffeine than normal, with a proposed cut-off value for abuse.

research Comprehensive HPLC and UPLC-MS/MS Analysis for the Multi-Component Detection of Hair Growth Compounds in Consumer Health Products

February 2026 in “Chromatographia”

A reliable method was developed to detect hair growth compounds in products, ensuring safety and compliance.

A Fast and Efficient UPLC-ESI-MS/MS Method for Detection, Identification, and Quantitative Analysis of Bioactive Substances in Medicinal Herbal Extracts for Preventing Hair Loss

research A Fast and Efficient UPLC-ESI-MS/MS Method for Detection, Identification, and Quantitative Analysis of Bioactive Substances in Medicinal Herbal Extracts for Preventing Hair Loss

4 citations , September 2015 in “Bulletin of the Korean Chemical Society”

Researchers developed a quick and sensitive method to identify and measure hair growth-promoting substances in a herbal mix.

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