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Glossary Pharmacokinetic Studies

investigate how drugs move through and are processed by the body

Pharmacokinetic Studies, often abbreviated as PK Studies, investigate how a drug is absorbed, distributed, metabolized, and excreted in the body. These studies help determine the appropriate dosage and frequency to ensure the drug's efficacy and safety.

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research Rapid determination of finasteride in human plasma by UPLC–MS/MS and its application to clinical pharmacokinetic study

18 citations , April 2010 in “Journal of Chromatography B”

This study describes a validated UPLC-MS/MS method for quantifying finasteride in human plasma, demonstrating higher specificity, improved resolution, increased sensitivity, and faster analysis times compared to conventional HPLC-MS/MS methods.

A Rapid, Simple, Specific Liquid Chromatographic–Electrospray Mass Spectrometry Method for the Determination of Finasteride in Human Plasma and Its Application to Pharmacokinetic Study

research A rapid, simple, specific liquid chromatographic–electrospray mass spectrometry method for the determination of finasteride in human plasma and its application to pharmacokinetic study

15 citations , November 2006 in “Journal of Pharmaceutical and Biomedical Analysis”

This study developed and validated a reliable method to measure finasteride levels in human plasma, which was successfully used to assess its pharmacokinetics after a 5 mg dose in healthy volunteers.

research A rapid, simple, liquid chromatographic-electrospray ionization, ion trap mass spectrometry method for the determination of finasteride in human plasma and its application to pharmacokinetic study.

5 citations , January 2012 in “PubMed”

This study developed and validated a reliable method using chromatography and mass spectrometry to accurately measure finasteride levels in human plasma.

Finasteride Quantification in Human Plasma by High-Performance Liquid Chromatography Coupled to Electrospray Ionization Tandem Mass Spectrometry: Application to a Comparative Pharmacokinetics Study

research Finasteride Quantification in Human Plasma by High-Performance Liquid Chromatography Coupled to Electrospray Ionization Tandem Mass Spectrometry. Application to a Comparative Pharmacokinetics Study

1 citations , April 2015 in “Drug research”

This study concluded that two different pharmaceutical formulations of finasteride were bioequivalent in terms of rate and extent of absorption based on pharmacokinetic evaluations in a randomized crossover study with 38 volunteers.

research Pharmacokinetic study in hairless rat after topical application of finasteride: single and repeated dose

January 2012 in “Journal of Investigative Dermatology”

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community Latest study on RU58841 done 19. August 2026.

25 upvotes 1 month ago

RU58841 can be absorbed systemically after topical application, but the study did not find immediate hormonal disruption. The study highlights the need for more research on long-term safety and effects of RU58841, as well as the importance of quality control in products from the grey market.

community With studies showing that 0.2mg Finasteride is almost as effective as 5mg at reducing DHT, why is every doctor prescribing 1mg?

252 upvotes 10 months ago

Finasteride is prescribed at 1mg because it is FDA-approved and proven effective, despite evidence that 0.2mg may similarly reduce DHT. The 1mg dose is more effective for hair growth, and lower doses are less available.

community Haunting study is making me considering cycling fin/dut

in Research/Science 158 upvotes 1 year ago

Concerns about the long-term effects of dutasteride and finasteride on fertility, with discussions on cycling these medications to mitigate risks. The conversation highlights skepticism about study methodologies and the importance of weighing treatment risks against potential fertility issues.

community PP405 2a study was a safety study. Some rational explaining.

22 upvotes 1 year ago

The conversation discusses the safety study of PP405, emphasizing that early trials focus on safety rather than efficacy, and that any efficacy data from such a short study should be viewed skeptically. It also highlights that the information released is primarily for securing funding, and that meaningful efficacy results are expected in later phases.

community Why can’t we just do another creatine study?

153 upvotes 1 year ago

Creatine may worsen hair loss in some, especially with androgenic alopecia, but evidence is mixed. Some users experience no hair loss when using creatine with minoxidil and finasteride, while others notice increased shedding.

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learn white tea

Is white tea more effective in topical hair products or as an oral supplement for hair growth? Neither topical nor oral white tea has any human clinical trial behind it for hair growth. Topical use has a more direct mechanistic rationale, but the only verifiable studies are a cell-culture EGCG experiment and a pharmacokinetic study with no hair outcomes.

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