Separation of Finasteride and Analogues

November 2001 in “ Journal of Chromatography B: Biomedical Sciences and Applications ”

Joseph Macek

finasteride analogues liquid chromatography mass spectrometry biological fluids metabolites extraction methods Propecia LC-MS-MS

TLDR Finasteride and analogues separated using LC-MS-MS technique.

This document from 21 years ago discusses the use of liquid chromatography and mass spectrometry for the separation and detection of finasteride and its analogues in biological fluids. LC-MS-MS is found to be the preferred technique due to its simple sample preparation procedure and short analysis time. The document also highlights the potential interference of metabolites in the analysis and the need for specific extraction methods to eliminate undesired effects.

View this study on sciencedirect.com →

Discuss this study in the Community →

Research cited in this study

4 / 4 results

research Finasteride

40 citations, April 1999 in “Drugs”

Finasteride treats enlarged prostate, improves urinary flow, but may cause sexual side effects.

research Finasteride

125 citations, January 1999 in “Drugs”

Finasteride effectively treats baldness but may cause sexual side effects.

Matrix Effect in Quantitative LC/MS/MS Analyses of Biological Fluids: A Method for Determination of Finasteride in Human Plasma at Picogram Per Milliliter Concentrations

research Matrix Effect in Quantitative LC/MS/MS Analyses of Biological Fluids: A Method for Determination of Finasteride in Human Plasma at Picogram Per Milliliter Concentrations

823 citations, February 1998 in “Analytical Chemistry”

Method detects finasteride in plasma at very low concentrations.

research Finasteride

86 citations, July 1993 in “Drugs”

Finasteride treats enlarged prostate, shrinks it, improves urination, but may cause sexual dysfunction and isn't for women or children.

Similar Research

5 / 1000+ results

research Matrix Effect in Quantitative LC/MS/MS Analyses of Biological Fluids: A Method for Determination of Finasteride in Human Plasma at Picogram Per Milliliter Concentrations

823 citations, February 1998 in “Analytical Chemistry”

Method detects finasteride in plasma at very low concentrations.

Influence of Saw Palmetto and Pygeum Africana Extracts on the Urinary Concentrations of Endogenous Anabolic Steroids: Relevance to Doping Analysis

research Influence of Saw Palmetto and Pygeum Africana Extracts on the Urinary Concentrations of Endogenous Anabolic Steroids: Relevance to Doping Analysis

2 citations, December 2020 in “Phytomedicine plus”

Taking Saw palmetto and Pygeum africana can change the levels of certain steroids in urine, which could cause confusion in doping tests.

Intracrine Androgen Biosynthesis, Metabolism, and Action Revisited

Separation of Finasteride and Analogues

Research cited in this study

research Finasteride

research Finasteride

research Matrix Effect in Quantitative LC/MS/MS Analyses of Biological Fluids: A Method for Determination of Finasteride in Human Plasma at Picogram Per Milliliter Concentrations

research Finasteride

Related Community Posts Join

community My experience and a discourse on “DUPA”

community Pyrilutamide real life results?

community 8 months on Fin and Min, with no change. Give up or switch to dut and add micro needling?

community I am actually regrowing my hairline without minoxidil or finasteride (mechanical stimulation)

community Been doing daily 3% topical peppermint oil for 6+ months (never used minoxidil). Have had growth that seems as good as minoxidil. Might strenghten the idea that peppermint is a good low-cost treatment, that potentially works by another route than minoxidil.

community Damn, the trash hormone DHT was losing so hard it pulled the "old social media post" card

Similar Research

research Matrix Effect in Quantitative LC/MS/MS Analyses of Biological Fluids: A Method for Determination of Finasteride in Human Plasma at Picogram Per Milliliter Concentrations

research Influence of Saw Palmetto and Pygeum Africana Extracts on the Urinary Concentrations of Endogenous Anabolic Steroids: Relevance to Doping Analysis

research Intracrine Androgen Biosynthesis, Metabolism, and Action Revisited

research A Stability Indicating UPLC Method for Finasteride and Its Related Impurities

research Relationships Between Cerebrospinal Fluid GABAergic Neurosteroid Levels and Symptom Severity in Men with PTSD