Separation of Finasteride and Analogues

November 2001 in “ Journal of Chromatography B: Biomedical Sciences and Applications ”

Joseph Macek

finasteride analogues liquid chromatography mass spectrometry biological fluids metabolites extraction methods Propecia LC-MS-MS

TLDR Finasteride and analogues separated using LC-MS-MS technique.

This document from 21 years ago discusses the use of liquid chromatography and mass spectrometry for the separation and detection of finasteride and its analogues in biological fluids. LC-MS-MS is found to be the preferred technique due to its simple sample preparation procedure and short analysis time. The document also highlights the potential interference of metabolites in the analysis and the need for specific extraction methods to eliminate undesired effects.