Isolation and Structural Identification of a Novel Minoxidil Analogue in an Illegal Dietary Supplement: Triaminodil

In 2017, a novel minoxidil analogue called triaminodil was discovered in an illegal dietary supplement marketed for hair growth. This compound, which made up about 0.5% of each capsule, differed from minoxidil by having a pyrrolidinyl group instead of a piperidinyl group. The identification was achieved using ultra-performance liquid chromatography, high-resolution mass spectrometry, and nuclear magnetic resonance spectroscopy. At the time of the study, there was no available data on the chemical, toxicological, or pharmacological properties of triaminodil. The study raised concerns about the health risks of unapproved analogues in dietary supplements and underscored the importance of vigilant screening of such products. The research was funded by the Ministry of Food and Drug Safety in Korea and received technical support from the Central Laboratory of Kangwon National University.