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GlossaryNuclear Magnetic Resonance Spectroscopy (NMR)

technique that uses magnetic fields to determine molecular structures

Nuclear Magnetic Resonance Spectroscopy (NMR) is a powerful analytical technique used to determine the structure of molecules. It works by placing a sample in a strong magnetic field and then measuring the interaction of atomic nuclei with radiofrequency waves. This interaction provides detailed information about the molecular structure, dynamics, and environment, making it invaluable in fields like chemistry, biology, and medicine.

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PH Dependence of the Coiled-Coil Structure of Keratin Intermediate Filament in Human Hair by 13C NMR Spectroscopy and the Mechanism of Its Disruption

research PH Dependence of the Coiled-Coil Structure of Keratin Intermediate Filament in Human Hair by 13C NMR Spectroscopy and the Mechanism of Its Disruption

7 citations, February 1998 in “Polymer journal”

Keratin structure in hair is stable at pH 5-6 but disrupts between pH 6-7.

research 1H NMR-Based Lipidomics of Rodent Fur: Species-Specific Lipid Profiles and SCD1 Inhibitor-Related Dermal Toxicity

5 citations, April 2014 in “Journal of Lipid Research”

SCD1 inhibitors can cause skin issues in rodents.

research The Effects of Finasteride on the Expression of Dazl, Tsga10, Sycp3, Prm2 Genes During Spermatogenesis in Testes of NMRI Mice

August 2020 in “DOAJ (DOAJ: Directory of Open Access Journals)”

Finasteride, at doses of 5mg or higher, may negatively affect male fertility by reducing the expression of certain genes involved in sperm production.

research Isolation and Structural Characterization of Degradation Products of Finasteride by Preparative HPLC, HRMS, and 2D NMR

May 2019 in “Asian Journal of Chemistry”

Finasteride forms three new products under acidic stress.

research The Effect of Finasteride on the Secretion of Testosterone, DHT, LH, FSH, and Tissue Factors in the Testis of NMRI Mice

June 2021 in “Archives of Advances in Biosciences”

Finasteride reduces sperm count and quality and alters hormone levels in mice.

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community How to increase Pyri concentration from 0.5% to 1% wihout using more volume ( 2ml x 2 per say for example )

in Chat 6 upvotes 3 months ago

OP wants to increase pyrilutamide concentration from 0.5% to 1% while already using finasteride. Users suggest waiting for a commercial 1% solution and caution against using grey market products.

community The New, Improved CB-03-01/Setipiprant Group Buy

27 upvotes 8 years ago

The group buy for CB-03-01, a topical anti-androgen for hair loss, was postponed and refunded due to issues with the product's form and solubility. The product, also known as Breezula, is an alternative to finasteride with fewer side effects, but its official release is delayed until 2021.

community Binding affinity of pyrilutamide!

in Update 167 upvotes 2 years ago

Pyrilutamide, a nonsteroidal antiandrogen drug under development for the potential treatment of androgenic alopecia. The conversation discusses its binding affinity to the androgen receptor and the timeline for possible availability after trials are completed in the United States and China.