TLDR A reliable method was created to measure tamsulosin in human blood.
The study developed a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method to measure tamsulosin levels in human serum, achieving high sensitivity with a lower limit of quantitation of 0.2 ng/mL and a lower limit of detection at 0.13 ng/mL. The method used d9-finasteride as an internal standard and required only 100 μL of serum, demonstrating high recovery rates and specificity. It was validated with samples from 3 treated and 3 untreated male subjects, showing reliable results within quantitation limits. This assay provided a simple, efficient, and sensitive alternative for clinical studies of benign prostatic hyperplasia (BPH) treatment, with potential adaptation for measuring finasteride.
25 citations
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June 2002 in “Steroids” 4-azasteroids, including finasteride, can inhibit 5α-reductase, helping treat conditions like enlarged prostate and hair loss.
70 citations
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November 2013 in “The BMJ” Tamsulosin for enlarged prostate may increase the risk of severe low blood pressure, especially when starting or restarting the medication.
January 2025 in “Heliyon” Tamsulosin and finasteride have similar effects on blood sugar control in men with type 2 diabetes.
7 citations
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November 2014 in “Clinical Therapeutics” Finasteride and tamsulosin hydrochloride can be safely taken together without significant interaction.
8 citations
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January 2011 in “Korean Journal of Andrology” The doxazosin plus tamsulosin combination improved symptoms effectively with fewer side effects.
20 citations
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June 2015 in “Hormone Molecular Biology and Clinical Investigation” Finasteride worsens erectile dysfunction and lowers testosterone in men with enlarged prostates, unlike tamsulosin.
20 citations
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June 2017 in “Hormone Molecular Biology and Clinical Investigation” Long-term use of dutasteride for enlarged prostate may worsen blood sugar, cholesterol, and erectile dysfunction.
