TLDR A reliable method was created to measure tamsulosin in human blood.
A method was developed and validated for extracting and quantifying tamsulosin from human serum using liquid chromatography-tandem mass spectrometry (LC-MS/MS). The process involved liquid-liquid extraction with methyl tert-butyl ether and achieved 99.9% analyte recovery. The method used an Ascentis Express C18 column and a triple quadrupole mass spectrometer, with a total run-time of 6 minutes. It demonstrated a limit of quantitation of 0.2 ng/mL and was validated for a linear range of 0.2-50 ng/mL, showing acceptable precision, accuracy, and stability. This method was applied in a clinical study on benign prostatic hyperplasia, serving as a measure of compliance in clinical research.
25 citations
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June 2002 in “Steroids” 4-azasteroids, including finasteride, can inhibit 5α-reductase, helping treat conditions like enlarged prostate and hair loss.
70 citations
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November 2013 in “The BMJ” Tamsulosin for enlarged prostate may increase the risk of severe low blood pressure, especially when starting or restarting the medication.
January 2025 in “Heliyon” Tamsulosin and finasteride have similar effects on blood sugar control in men with type 2 diabetes.
7 citations
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November 2014 in “Clinical Therapeutics” Finasteride and tamsulosin hydrochloride can be safely taken together without significant interaction.
8 citations
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January 2011 in “Korean Journal of Andrology” The doxazosin plus tamsulosin combination improved symptoms effectively with fewer side effects.
20 citations
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June 2015 in “Hormone Molecular Biology and Clinical Investigation” Finasteride worsens erectile dysfunction and lowers testosterone in men with enlarged prostates, unlike tamsulosin.
20 citations
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June 2017 in “Hormone Molecular Biology and Clinical Investigation” Long-term use of dutasteride for enlarged prostate may worsen blood sugar, cholesterol, and erectile dysfunction.
