Simultaneous Quantitative Analysis of Tamsulosin and Finasteride in Pharmaceutical Dosage Form by U-HPLC Tandem Mass Spectrometry

March 2014 in “ European Journal of Chemistry ”

Dalia Mohamed, Shereen Mowaka, Ahmed Mostafa

TLDR Method measures tamsulosin and finasteride in medicine accurately.

The paper presents a method for the simultaneous quantitative analysis of tamsulosin and finasteride in pharmaceutical dosage forms using U-HPLC tandem mass spectrometry. The method was validated for linearity, accuracy, precision, and robustness. The authors concluded that the optimized LC-MS/MS method can be used for the routine analysis of tamsulosin and finasteride in pharmaceutical dosage forms.

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Research cited in this study

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Validated RP-HPLC and TLC Methods for Simultaneous Estimation of Tamsulosin Hydrochloride and Finasteride in Combined Dosage Forms

research Validated RP-HPLC and TLC Methods for Simultaneous Estimation of Tamsulosin Hydrochloride and Finasteride in Combined Dosage Forms

26 citations, June 2010 in “Acta Pharmaceutica”

Methods accurately measure tamsulosin hydrochloride and finasteride in combined dosages.

research Polarographic Behavior and Determination of Finasteride

21 citations, February 2003 in “Farmaco”

Method quickly measures finasteride concentration in capsules.

research LC Determination of Finasteride and Its Application to Storage Stability Studies

27 citations, July 2001 in “Journal of Pharmaceutical and Biomedical Analysis”

Finasteride remains stable for two years with proper storage.

Matrix Effect in Quantitative LC/MS/MS Analyses of Biological Fluids: A Method for Determination of Finasteride in Human Plasma at Picogram Per Milliliter Concentrations

research Matrix Effect in Quantitative LC/MS/MS Analyses of Biological Fluids: A Method for Determination of Finasteride in Human Plasma at Picogram Per Milliliter Concentrations

823 citations, February 1998 in “Analytical Chemistry”

Method detects finasteride in plasma at very low concentrations.

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Simultaneous Quantitative Analysis of Tamsulosin and Finasteride in Pharmaceutical Dosage Form by U-HPLC Tandem Mass Spectrometry

research Simultaneous Quantitative Analysis of Tamsulosin and Finasteride in Pharmaceutical Dosage Form by U-HPLC Tandem Mass Spectrometry

2 citations, March 2014 in “European Journal of Chemistry”

Method measures tamsulosin and finasteride in medicine accurately.