RP-HPLC Assay Method for Simultaneous Estimation of Tamsulosin Hydrochloride and Finasteride in Pharmaceutical Dosage Form

    January 2012 in “ Analytical chemistry, an Indian journal ”
    Pritam Jain, Abdul R.Bakhshi, Sanjay B. Bari, Sanjay J. Surana, Amar Chaudhari
    TLDR A reliable method was developed to accurately measure tamsulosin hydrochloride and finasteride in tablets.
    The study developed a Reverse Phase High Performance Liquid Chromatographic (RP-HPLC) method for the simultaneous estimation of tamsulosin hydrochloride and finasteride in tablet form. The method used a methanol: water mobile phase and UV detection, with retention times of 2.68 and 7.33 minutes for tamsulosin hydrochloride and finasteride, respectively. It was validated for precision, accuracy, linearity, and other parameters, showing high sensitivity with limits of detection at 0.28 µg/ml for tamsulosin hydrochloride and 0.85 µg/ml for finasteride. The method demonstrated high accuracy with recovery rates between 99.9%-100.54% for tamsulosin hydrochloride and 99.83%-100.92% for finasteride, and a % RSD below 2.0, indicating high precision. There was no interference from tablet excipients.
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