RP HPLC Method for the Determination of Finasteride and Tamsulosin in Bulk and Pharmaceutical Formulations

    January 2011 in “ Der Pharmacia Lettre ”
    Manish Kumar Thimmaraju, Venkat K. Rao, Srikanth Gurrala
    TLDR The method accurately measures Finasteride and Tamsulosin in tablets without interference.
    A reverse phase high performance liquid chromatographic (RP HPLC) method was developed and validated for determining Finasteride and Tamsulosin in bulk and tablet forms. The method demonstrated that tablet excipients did not interfere with drug quantification. The HPLC used a Shimadzu system with a hypersil ODS C18 column and a mobile phase of acetonitrile and KH2PO4 buffer. Detection occurred at 240 nm, with linearity ranges of 125-625 mg/ml for Finasteride and 10-50 mg/ml for Tamsulosin. The method showed adequate sensitivity, reproducibility, and specificity, with satisfactory accuracy and precision, achieving recovery rates of 100.76% for Finasteride and 99.06% for Tamsulosin.
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