Spectrophotometric and Stability Indicating RP-HPLC-PDA Method for Simultaneous Determination of Finasteride and Tamsulosin in Combined Tablet Dosage Form

    December 2009 in “ Asian Journal of Research in Chemistry ”
    Amol H. Kategaonkar, Dhaval Patel, Bhushan P Itkar, Vishnu P. Choudhari, Bhanudas S. Kuchekar, A. G. Nikalje
    TLDR The methods accurately measure Finasteride and Tamsulosin in tablets.
    The study developed and validated simple, accurate, precise, and sensitive ultraviolet spectrophotometric and stability-indicating reversed-phase high-performance liquid chromatographic (RP-HPLC) methods for the simultaneous estimation of Tamsulosin and Finasteride in combined tablet dosage form. The spectroscopic method used an absorbance correction method with methanol as a solvent, while the RP-HPLC method employed a Waters Symmetry C18 column with a mobile phase of Methanol: Water: THF (75: 15: 10 v/v/v) and a PDA detector at 275 nm. The methods were successfully applied to pharmaceutical formulations, with results validated statistically and through recovery studies.
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