Spectrophotometric and Stability Indicating RP-HPLC-PDA Method for Simultaneous Determination of Finasteride and Tamsulosin in Combined Tablet Dosage Form

The study developed and validated simple, accurate, precise, and sensitive ultraviolet spectrophotometric and stability-indicating reversed-phase high-performance liquid chromatographic (RP-HPLC) methods for the simultaneous estimation of Tamsulosin and Finasteride in combined tablet dosage form. The spectroscopic method used an absorbance correction method with methanol as a solvent, while the RP-HPLC method employed a Waters Symmetry C18 column with a mobile phase of Methanol: Water: THF (75: 15: 10 v/v/v) and a PDA detector at 275 nm. The methods were successfully applied to pharmaceutical formulations, with results validated statistically and through recovery studies.