Spectrophotometric and Stability Indicating RP-HPLC-PDA Method for Simultaneous Determination of Finasteride and Tamsulosin in Combined Tablet Dosage Form

    December 2009 in “ Asian Journal of Research in Chemistry ”
    Amol H. Kategaonkar, Dhaval Patel, Bhushan P Itkar, Vishnu P. Choudhari, Bhanudas S. Kuchekar, A. G. Nikalje
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    Frontline, gold standard treatment for combatting androgenic alopecia

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    Studysummary This study developed and validated ultraviolet spectrophotometric and reversed phase high performance liquid chromatographic methods for simultaneously estimating Tamsulosin and Finasteride in tablet form, showing statistical validation and effectiveness in pharmaceutical analysis. Our plain-language summary of this paper — not a Tressless recommendation.
    The study developed and validated simple, accurate, precise, and sensitive ultraviolet spectrophotometric and stability-indicating reversed-phase high-performance liquid chromatographic (RP-HPLC) methods for the simultaneous estimation of Tamsulosin and Finasteride in combined tablet dosage form. The spectroscopic method used an absorbance correction method with methanol as a solvent, while the RP-HPLC method employed a Waters Symmetry C18 column with a mobile phase of Methanol: Water: THF (75: 15: 10 v/v/v) and a PDA detector at 275 nm. The methods were successfully applied to pharmaceutical formulations, with results validated statistically and through recovery studies.
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