Simultaneous Estimation of Finasteride and Tamsulosin Hydrochloride in Pharmaceutical Dosage Forms by UV Spectrophotometric, RP-HPLC, and HPTLC Methods.

    September 2007
    M S Suganya
    TLDR Three reliable methods were developed to measure Finasteride and Tamsulosin Hydrochloride in medicines.
    The study successfully developed three analytical methods—RP-HPLC, HPTLC, and UV Spectrophotometry—for the simultaneous quantification of Finasteride and Tamsulosin Hydrochloride in pharmaceutical dosage forms. The RP-HPLC method demonstrated high selectivity, precision, and accuracy, with retention times of 7.11 minutes for Finasteride and 2.65 minutes for Tamsulosin Hydrochloride. The HPTLC method was noted for its ease and speed, using a specific mobile phase and scanning wavelength. The Q-absorbance ratio method was highlighted for its simplicity and cost-effectiveness. All methods were validated according to ICH guidelines, showing precision (%RSD below 2) and accuracy, making them reliable for routine analysis.
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