RP-HPLC Method for Simultaneous Estimation of Finasteride and Tamsulosin in Tablet Formulations
January 2015
in “
INDONESIAN JOURNAL OF PHARMACY
”
TLDR A reliable method was developed to measure Tamsulosin and Finasteride in tablets accurately.
The study aimed to develop a simple and precise RP-HPLC method for the simultaneous estimation of Tamsulosin and Finasteride in bulk and tablet formulations. The method utilized a Spherisorb C-18 column with an isocratic flow and detection at 210 nm, using a mobile phase of methanol and phosphate buffer. It demonstrated a linear response for Tamsulosin and Finasteride within specific concentration ranges, with limits of detection and quantitation established for both drugs. The recovery rates were high, and the low %RSD values indicated good precision and stability. The method was concluded to be selective and potentially useful for estimating these drugs in combined dosage forms.
