UV Spectrophotometric Method for Simultaneous Determination of Finasteride and Tamsulosin in Combined Dosage Form

In 2011, researchers developed a UV spectrophotometric method to simultaneously measure finasteride and tamsulosin in tablet form. The method showed specificity, speed, simplicity, and sensitivity, with maximum absorption for finasteride at 219 nm and for tamsulosin at 224 nm in methanol. The linearity for finasteride was within 12.5-62.5 µg/ml (correlation coefficient of 0.9981) and for tamsulosin was 1-5 µg/ml (correlation coefficient of 0.9989). The method demonstrated high precision and accuracy, with a relative standard deviation of 0.5974 for finasteride and 0.4096 for tamsulosin. Recovery rates ranged from 99.4% to 99.76% for finasteride and 97.5% to 99.85% for tamsulosin, indicating the method's reliability in quantifying these drugs in pharmaceuticals without excipient interference. The study concluded that this method could be routinely used for determining finasteride and tamsulosin in bulk and pharmaceutical forms.