Determination of the Dissolution of Finasteride Tablets by HPLC

    January 2003 in “ Pharmaceutical Journal of Chinese People's Liberation Army ”
    Xin Chen
    TLDR The method accurately measures finasteride tablet dissolution.
    The study developed a high-performance liquid chromatography (HPLC) method to determine the dissolution of finasteride tablets. The method utilized a LUNA 5μm C18 column with a mobile phase of 2.5 mmol·L⁻¹ phosphoric acid-acetonitrile (1:1) and a detection wavelength of 220 nm. The detection limit for finasteride was approximately 2 ng, and the calibration curve was linear between 1.4 and 16.8 μg·ml⁻¹ with a correlation coefficient (r) of 0.9999. The method demonstrated an average recovery rate of 99.61% with a relative standard deviation (RSD) of 1.05% across 6 samples, indicating that the method was simple, quick, and accurate.
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