A Stability-Indicating HPLC Method to Determine Finasteride in a Tablet Formulation
December 2002
in “
Journal of Liquid Chromatography & Related Technologies
”
![Image of study](/images/research/095efb4b-fbd4-4bc3-9957-bf1be663fe72/medium/2442.jpg)
TLDR New method quickly and accurately measures finasteride in tablets.
This document describes a validated HPLC method for determining the amount of finasteride in a tablet formulation. The method was found to be simple, rapid, reproducible, economic, and stability-indicating. The accuracy of the assay was assessed at 80, 100, and 120% of finasteride by recovery experiments, using tablets from the same lot of a commercial formulation. The method was developed by evaluating the effect of mobile phase proportion on retention time and tailing factor, and precision was considered at two levels of ICH suggestions: repeatability and intermediate precision.