Stability-Indicating Micellar Electrokinetic Chromatography Method for Determination of Finasteride in Pharmaceutical Preparations

June 2012 in “ Journal of Liquid Chromatography & Related Technologies ”

Mehmet Gokhan Caglayan, Ismail Murat Palabiyik, Feyyaz Onur

finasteride micellar electrokinetic chromatography MEKC pharmaceutical preparations degradation products impurities commercial tablets quality control analysis Propecia

TLDR Method accurately measures finasteride concentration in medicine.

This document describes a method for determining the concentration of finasteride in pharmaceutical preparations using micellar electrokinetic chromatography (MEKC). The method was optimized, validated, and found to be specific, accurate, precise, and robust. The MEKC method was able to separate finasteride from its degradation products and other impurities. The method was also found to be suitable for the analysis of finasteride in commercial tablets. The authors suggest that the MEKC method can be used for routine quality control analysis of finasteride in pharmaceutical preparations.

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Research cited in this study

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research Rapid Determination of Finasteride in Human Plasma by UPLC-MS/MS and Its Application to Clinical Pharmacokinetic Study

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research Validated RP-HPLC and TLC Methods for Simultaneous Estimation of Tamsulosin Hydrochloride and Finasteride in Combined Dosage Forms

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21 citations , May 2008 in “Talanta”

New, cheaper method measures finasteride in tablets accurately and quickly.

research A New Spectrophotometric Method for the Determination of Finasteride in Tablets

22 citations , July 2007 in “Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy”

New method accurately measures finasteride in tablets.

A Rapid, Simple, Specific Liquid Chromatographic–Electrospray Mass Spectrometry Method for the Determination of Finasteride in Human Plasma and Its Application to Pharmacokinetic Study

research A Rapid, Simple, Specific Liquid Chromatographic–Electrospray Mass Spectrometry Method for the Determination of Finasteride in Human Plasma and Its Application to Pharmacokinetic Study

15 citations , March 2007 in “Journal of Pharmaceutical and Biomedical Analysis”

Method measures finasteride in plasma, suitable for pharmacokinetic studies.

research Determination of Finasteride in Tablets by High Performance Liquid Chromatography

13 citations , January 2007 in “E-journal of Chemistry”

Found accurate way to measure finasteride in tablets.

research Sensitive Bromatometric Assay Methods for Finasteride in Pharmaceuticals

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Three cost-effective methods accurately measure finasteride in pharmaceuticals, better than current techniques.

research A Stability-Indicating HPLC Method to Determine Finasteride in a Tablet Formulation

19 citations , December 2002 in “Journal of Liquid Chromatography & Related Technologies”

New method quickly and accurately measures finasteride in tablets.

research Separation of Finasteride and Analogues

11 citations , November 2001 in “Journal of Chromatography B: Biomedical Sciences and Applications”

Finasteride and analogues separated using LC-MS-MS technique.

research LC Determination of Finasteride and Its Application to Storage Stability Studies

27 citations , July 2001 in “Journal of Pharmaceutical and Biomedical Analysis”

Finasteride remains stable for two years with proper storage.

research Determination of Finasteride in Human Plasma by Liquid-Liquid Extraction and High-Performance Liquid Chromatography

24 citations , February 2000 in “Journal of Chromatography B: Biomedical Sciences and Applications”

Valid method measures finasteride in plasma, simple, fast, and affordable.

research Finasteride

40 citations , April 1999 in “Drugs”

Finasteride treats enlarged prostate, improves urinary flow, but may cause sexual side effects.

Determination of Finasteride and Related Compounds by Reversed-Phase High Performance Liquid Chromatography: Choosing the Mobile Phase Composition

research Determination of Finasteride and Related Compounds by Reversed-Phase High Performance Liquid Chromatography: Choosing the Mobile Phase Composition

9 citations , January 1999 in “Journal of Liquid Chromatography & Related Technologies”

Best results found using acetonitrile, water, and trifluoroacetic acid or methanol mixture.

High-Performance Liquid Chromatographic Determination of Finasteride in Human Plasma Using Direct Injection with Column Switching

research High-Performance Liquid Chromatographic Determination of Finasteride in Human Plasma Using Direct Injection with Column Switching

29 citations , February 1996 in “Journal of Chromatography B: Biomedical Sciences and Applications”

New method detects finasteride in plasma quickly and accurately without clean-up.

Picogram Determination of Finasteride in Human Plasma and Semen by High-Performance Liquid Chromatography with Atmospheric-Pressure Chemical-Ionization Tandem Mass Spectrometry

research Picogram Determination of Finasteride in Human Plasma and Semen by High-Performance Liquid Chromatography with Atmospheric-Pressure Chemical-Ionization Tandem Mass Spectrometry

45 citations , August 1994 in “Journal of Chromatography B: Biomedical Sciences and Applications”

Method detects finasteride in plasma and semen with high sensitivity and accuracy.

research High-Performance Liquid Chromatographic Method for the Determination of Finasteride in Human Plasma at Therapeutic Doses

19 citations , May 1991 in “Journal of Chromatography B: Biomedical Sciences and Applications”

Reliable method detects finasteride in human plasma at low doses.

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