Stability-Indicating Micellar Electrokinetic Chromatography Method for Determination of Finasteride in Pharmaceutical Preparations

    June 2012 in “ Journal of Liquid Chromatography & Related Technologies ”
    Mehmet Gokhan Caglayan, Ismail Murat Palabiyik, Feyyaz Onur
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    TLDR Method accurately measures finasteride concentration in medicine.
    This document describes a method for determining the concentration of finasteride in pharmaceutical preparations using micellar electrokinetic chromatography (MEKC). The method was optimized, validated, and found to be specific, accurate, precise, and robust. The MEKC method was able to separate finasteride from its degradation products and other impurities. The method was also found to be suitable for the analysis of finasteride in commercial tablets. The authors suggest that the MEKC method can be used for routine quality control analysis of finasteride in pharmaceutical preparations.
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