Voltammetric Reduction of Finasteride at Mercury Electrode and Its Determination in Tablets

January 2008 in “ Talanta ”

Alejandro Álvarez-Lueje, Stephanie Brain-Isasi, Luis J. Núñez-Vergara, Juan A. Squella

finasteride differential pulse voltammetry DPP ethanol H₂SO4 pharmaceutical forms Propecia sulfuric acid

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Studysummary New, cheaper method measures finasteride in tablets accurately and quickly.

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The study proposes a novel method for determining the concentration of finasteride in tablets using differential pulse voltammetry (DPP) in an ethanol/0.0625 mol L-¹ H₂SO4 (30/70) solution medium. The method is less expensive and less time-consuming than the standard HPLC method, and does not require treatment of the sample. The DPP-developed method was adequate for the finasteride determination in pharmaceutical forms as that exhibited an adequate accuracy, reproducibility and selectivity.

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