Synchronous Fluorescence as a Green and Selective Method for the Simultaneous Determination of Finasteride and Tadalafil in Dosage Form and Spiked Human Plasma

    May 2023 in “ Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy ”
    Hesham Salem, Amany Abdelaziz, Mariam Galal, Maha Hussien, Nadeen Emad, Asmaa E. Batekh, Mohamed Karem, Deena A. Moukhtar
    TLDR A new green method accurately measures finasteride and tadalafil in drugs and plasma.
    The study presents a sensitive and environmentally friendly first derivative synchronized spectrofluorometric method for the simultaneous quantitative analysis of finasteride and tadalafil in raw materials, pharmaceutical preparations, and spiked human plasma. By using sodium dodecyl sulfate (SDS) to enhance fluorescence intensity and resolving overlapping spectra through first derivative synchronization, the method achieved high sensitivity and accuracy, with recovery rates of 99.62% for tadalafil and 100.19% for finasteride. The approach was evaluated for its environmental impact using various green metrics and was found to be superior to previously published methods.
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