Synchronous Fluorescence as a Green and Selective Method for the Simultaneous Determination of Finasteride and Tadalafil in Dosage Form and Spiked Human Plasma

    May 2023 in “ Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy ”
    Hesham Salem, Amany Abdelaziz, Mariam Galal, Maha Hussien, Nadeen Emad, Asmaa E. Batekh, Mohamed Karem, Deena A. Moukhtar
    TLDR A new green method accurately measures finasteride and tadalafil in drugs and plasma.
    The study presents a sensitive and environmentally friendly first derivative synchronized spectrofluorometric method for the simultaneous quantitative analysis of finasteride and tadalafil in raw materials, pharmaceutical preparations, and spiked human plasma. By using sodium dodecyl sulfate (SDS) to enhance fluorescence intensity and resolving overlapping spectra through first derivative synchronization, the method achieved high sensitivity and accuracy, with recovery rates of 99.62% for tadalafil and 100.19% for finasteride. The approach was evaluated for its environmental impact using various green metrics and was found to be superior to previously published methods.
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      community Is this true? Is long term taking fin harmful to the liver?

      in Chat  127 upvotes 1 year ago
      The conversation discusses whether long-term use of finasteride (Fin) is harmful to the liver, with various opinions on side effects and comparisons to other substances. Specific treatments mentioned include finasteride, minoxidil (Min), and RU58841 (RU).
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      community Tadafil + finasteride seems to be working better

      in Treatment  23 upvotes 1 month ago
      Tadalafil combined with finasteride seems to improve hair condition for the original poster, who has experienced gradual improvement in hair thinning. Other users discuss the effects of tadalafil on blood flow and its potential benefits for hair growth.

      community Physician here AMA – 30M oral Fin 1-1.25 mg daily

      in Update  47 upvotes 2 years ago
      Hair loss treatments, specifically the use of finasteride, microneedling and potentially oral minoxidil. People discussed their experiences with finasteride, its effects on sexual behaviors, as well as potential solutions such as tadalafil or using other growth factor signal peptides for hope in curing male pattern baldness.

      community So depressed and upset with how much progress I’ve lost

      in Chat  51 upvotes 1 year ago
      A 20-year-old started taking finasteride for hair loss at 18, saw improvement, but developed erectile dysfunction (ED) after taking accutane. Despite stopping both medications, ED persisted, and hair loss worsened. Advice given includes considering tadalafil for ED, resuming finasteride, using minoxidil, and addressing psychological factors through positive thinking and lifestyle changes.

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