Selective and Rapid Determination of Tadalafil and Finasteride Using Solid Phase Extraction by High Performance Liquid Chromatography and Tandem Mass Spectrometry

    February 2018 in “ Journal of Pharmaceutical and Biomedical Analysis ”
    Nagaraju Pappula, Balaji Kodali, Peda Varma Datla
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    TLDR Quick, selective detection of tadalafil and finasteride in human plasma developed.
    The paper presents a method for quickly and selectively detecting tadalafil and finasteride in human plasma using solid phase extraction by high performance liquid chromatography and tandem mass spectrometry. The method is useful for studying the pharmacokinetics of these drugs, which are used to treat benign prostatic hyperplasia. The study developed a reliable and accurate way to measure tadalafil and finasteride levels in plasma samples, which could be useful for monitoring these drugs in patients with benign prostatic hyperplasia and lower urinary tract symptoms. However, the study did not investigate the effects of these drugs on hair growth or hair loss.
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