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research Spermidine/spermine-N¹-acetyltransferase: a key metabolic regulator

305 citations , March 2008 in “AJP Endocrinology and Metabolism”

This article reviews the regulation and roles of spermidine/spermine-N(1)-acetyltransferase (SSAT) in polyamine metabolism and its potential as a target in cancer and other diseases, without reporting new experimental results.

research Species Differences in Prostatic Steroid 5α-Reductases of Rat, Dog, and Human

193 citations , August 1985 in “Endocrinology”

This study found significant species differences in the enzyme activity and inhibitor affinities of prostatic 5α-reductases from rats, dogs, and humans, with variable potencies for different 3-oxo-4-azasteroid inhibitors across species.

research Genetically Altered Expression of Spermidine/Spermine N1-Acetyltransferase Affects Fat Metabolism in Mice via Acetyl-CoA

128 citations , December 2006 in “Journal of Biological Chemistry”

This study found that overexpression of the enzyme spermidine/spermine N1-acetyltransferase in mice was associated with increased fat oxidation and a leaner phenotype, while knock-out mice exhibited increased fat accumulation.

research Activation of Polyamine Catabolism Profoundly Alters Tissue Polyamine Pools and Affects Hair Growth and Female Fertility in Transgenic Mice Overexpressing Spermidine/SpermineN 1-Acetyltransferase

124 citations , July 1997 in “Journal of Biological Chemistry”

This study found that overexpression of an enzyme in transgenic mice led to distorted polyamine levels, resulting in permanent hair loss and female infertility.

research CHRONIC TREATMENT WITH FINASTERIDE DAILY DOES NOT AFFECT SPERMATOGENESIS OR SEMEN PRODUCTION IN YOUNG MEN

104 citations , October 1999 in “The Journal of Urology”

This study concluded that daily treatment with 1 mg finasteride did not affect spermatogenesis or semen production in young men and had small, reversible effects on prostate volume and serum PSA.

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Community Join

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community Spearmint tea for hair regrowth

3 upvotes 10 months ago

Spearmint tea and inositol are discussed as potential treatments for hair regrowth, but their effectiveness is questioned. Alternatives like green tea, MSM, and evening primrose oil are suggested for hair health.

community Spending $10K on a hair transplant in the U.S. vs $5,000 for one in Turkey

2214 upvotes 1 year ago

Hair transplants cost more in the U.S. than in Turkey, but quality varies. Proper research is essential, as aggressive transplants can exhaust donor hair, and finasteride only slows hair loss.

community How much do y’all spend on dutasteride a month?

in Chat 6 upvotes 5 months ago

People spend varying amounts on hair loss treatments like dutasteride, finasteride, and minoxidil, with costs ranging from $5 to over €220 depending on the source and quantity. Some users report side effects, while others discuss strategies for obtaining prescriptions and managing costs.

community Before you spend another dollar on treatments please check your ferritin and thyroid

205 upvotes 2 months ago

Check ferritin, thyroid, and vitamin D levels before spending on hair loss treatments. Addressing deficiencies can slow hair shedding and save money.

community Dutasteride and Sperm Volume concern

in Finasteride/Dutasteride 5 upvotes 4 months ago

Dutasteride can significantly reduce sperm volume, with some users experiencing up to a 90% decrease. While some users report adaptation over time, others suggest switching to finasteride if side effects are too severe.

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learn spearmint

learn Hair Transplant

Does transplanted hair require special care? Transplanted hair generally requires no special care after initial healing.
What is the best treatment for hair loss, specifically regarding hair transplants? Providers say there is no single best treatment: the choice depends on the person, with minoxidil and finasteride the common medicines and FUE a common surgical option. Only a minority of the clinics surveyed call a transplant permanent, and surgery does not stop hair loss in the hair around the grafts.

learn Castor oil

Does any castor oil work or do you have to look for a special one? Cold-pressed castor oil is generally more effective for hair growth than others.

learn vitamin A

Are you unknowingly overdoing vitamin A? It could be speeding up hair loss linked to hormones like DHT. Sustained vitamin A intake above the tolerable upper limit (3,000 mcg/day of retinol for adults) is linked in case reports to diffuse hair shedding; the claim that it amplifies DHT-driven hair loss has no published human evidence behind it.

learn Hair Fibers

Do hair fibers wash out easily, or do you need a special shampoo to remove them? There is no published trial comparing shampoos for removing hair fibers. Because the fibers cling by static rather than bonding chemically, and because users consistently report they rinse out with ordinary shampoo, the specialist fiber-removal shampoos do not appear to be necessary; a clarifying shampoo may help when fibers are layered under hairspray or gel.

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