A Rapid, Simple, Specific Liquid Chromatographic–Electrospray Mass Spectrometry Method for the Determination of Finasteride in Human Plasma and Its Application to Pharmacokinetic Study

    March 2007 in “ Journal of Pharmaceutical and Biomedical Analysis ”
    Fang-Qiu Guo, Lan-Fang Huang, Kin-Ping Wong, Dai Yunhui, Yawen Li, Yi-Zeng Liang, Kelong Huang, Kejun Zhong, Mingjian Wu
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    TLDR Method measures finasteride in plasma, suitable for pharmacokinetic studies.
    This paper describes a method for measuring the concentration of finasteride in human plasma using liquid chromatography-electrospray mass spectrometry. The method was validated for selectivity, linearity, precision, accuracy, and recovery. A pharmacokinetic study was conducted on 24 healthy male volunteers who received a 5 mg dose of finasteride. The developed method was found to be sensitive and reliable for determining the concentration of finasteride in human plasma. The study demonstrated that the method is suitable for pharmacokinetic studies.
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