A Rapid, Simple, Specific Liquid Chromatographic–Electrospray Mass Spectrometry Method for the Determination of Finasteride in Human Plasma and Its Application to Pharmacokinetic Study

    November 2006 in “ Journal of Pharmaceutical and Biomedical Analysis ”
    Fang-Qiu Guo, Lan-Fang Huang, Kin-Ping Wong … Mingjian Wu
    Studysummary This study developed and validated a reliable method to measure finasteride levels in human plasma, which was successfully used to assess its pharmacokinetics after a 5 mg dose in healthy volunteers.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on sciencedirect.com →
    Discuss this study in the Community →

    Research cited in this study 12

    1. Bioequivalence Study of Finasteride Drug Research · 2011
    2. Polarographic Behavior and Determination of Finasteride Farmaco · 2003
    3. Separation of Finasteride and Analogues Journal of Chromatography B: Biomedical Sciences and Applications · 2001
    4. LC Determination of Finasteride and Its Application to Storage Stability Studies Journal of Pharmaceutical and Biomedical Analysis · 2001
    5. Determination of Finasteride in Human Plasma by Liquid-Liquid Extraction and High-Performance Liquid Chromatography Journal of Chromatography B: Biomedical Sciences and Applications · 2000
    6. Matrix Effect in Quantitative LC/MS/MS Analyses of Biological Fluids: A Method for Determination of Finasteride in Human Plasma at Picogram Per Milliliter Concentrations Analytical Chemistry · 1998
    7. Finasteride in Biological Fluids: Extraction and Separation by a Graphitized Carbon Black Cartridge and Quantification by High-Performance Liquid Chromatography Journal of Chromatography B: Biomedical Sciences and Applications · 1997
    8. High-Performance Liquid Chromatographic Determination of Finasteride in Human Plasma Using Direct Injection with Column Switching Journal of Chromatography B: Biomedical Sciences and Applications · 1996
    9. Synthesis of 5,6,6-[2H3]Finasteride and Quantitative Determination of Finasteride in Human Plasma at Picogram Level by an Isotope-Dilution Mass Spectrometric Method Journal of Chromatography B: Biomedical Sciences and Applications · 1995
    10. Picogram Determination of Finasteride in Human Plasma and Semen by High-Performance Liquid Chromatography with Atmospheric-Pressure Chemical-Ionization Tandem Mass Spectrometry Journal of Chromatography B: Biomedical Sciences and Applications · 1994
    11. Finasteride Drugs · 1993
    12. Species Differences in Prostatic Steroid 5α-Reductases of Rat, Dog, and Human Endocrinology · 1985

    Related research 1

    1. A Rapid, Simple, Specific Liquid Chromatographic–Electrospray Mass Spectrometry Method for the Determination of Finasteride in Human Plasma and Its Application to Pharmacokinetic Study Journal of Pharmaceutical and Biomedical Analysis · 2006