Optimization of Minoxidil Microemulsions Using Fractional Factorial Design Approach

    Napaphak Jaipakdee, Ekapol Limpongsa, Thaned Pongjanyakul
    Image of study
    TLDR The study found a way to improve a skin-applied minoxidil formula using a specific design method.
    The 2014 study successfully optimized minoxidil (MX) microemulsions for topical delivery using a fractional factorial design approach. Key findings included that MX solubility was enhanced with higher ethanol concentrations and reduced surfactant and limonene levels. Permeation flux improved with lower Tween 20 and surfactant concentrations and higher ethanol levels, while skin deposition increased with lower concentrations of Tween 20 and surfactant. The study also determined that lag time for MX permeation was unaffected by the formulation variables. The optimized microemulsion, which showed high MX solubility, permeation flux, and skin deposition, was formulated with low levels of Tween 20, surfactant, and limonene, and a high level of ethanol. The study concluded that the fractional factorial design is an effective method for formulating MX-loaded microemulsions with desirable characteristics for potential use in topical delivery. However, the number of experiments and samples analyzed was not specified in the summary provided.
    Discuss this study in the Community →

    Research cited in this study

    4 / 4 results

    Related Community Posts Join

    6 / 1000+ results

      community Reql minoxidil vs fake minoxidil (right)

      in Minoxidil  239 upvotes 4 days ago
      Counterfeit minoxidil is a concern, with users suggesting buying from reputable sources like Costco to ensure authenticity. A bleach test can help verify genuine minoxidil.

      community Smoking minoxidil, the theory that changes everything.

      in Minoxidil  591 upvotes 5 days ago
      A user humorously suggested smoking minoxidil in a blunt as an alternative hair growth method, sparking a satirical discussion on unconventional and unsafe ways to use minoxidil. The conversation included various suggestions like oral pills, rectal administration, and other absurd methods, with some users warning against the dangers of such practices.

      community Why don't Minoxidil regenerated hairs become terminal on the head?

      in Minoxidil  102 upvotes 5 days ago
      Minoxidil helps hair growth by increasing blood flow and prolonging the growth phase, but it doesn't address the root cause of hair loss, such as DHT sensitivity. Finasteride can help maintain some gains by blocking DHT, but stopping Minoxidil often leads to hair loss because the new hairs are dependent on it.

      community Be careful with minoxidil, even if it's just foam.

      in Minoxidil  12 upvotes 6 days ago
      Minoxidil caused side effects like chest pain and tinnitus for the user, leading them to stop using it and consider switching to finasteride with microneedling. Other users shared similar experiences with minoxidil, while some reported no issues, highlighting varied individual reactions.

      community 8 months on oral minoxidil. No sign of regrowth.

      in Minoxidil  14 upvotes 1 week ago
      The user has been taking 2mg oral minoxidil and 1mg finasteride but has seen no hair regrowth after 8 months, leading to concerns about being a non-responder. They are considering increasing the minoxidil dosage or switching to dutasteride, while also using keto shampoo and microneedling, but remain skeptical about the effectiveness of minoxidil.

    Related Research

    1 / 1 results