Transcutol-Containing Vesicles for Topical Delivery of Minoxidil

May 2010 in “ Journal of Drug Targeting ”

Simona Mura, Maria Manconi, Donatella Valenti, Chiara Sinico, Amparo Vila, Anna Maria Fadda

Transcutol vesicles topical delivery minoxidil hair growth hair loss skin penetration entrapment efficiency lipidic bilayer viscoelastic behavior Rogaine

Studysummary This study found that Transcutol-containing vesicles improved the delivery of minoxidil to deeper skin layers in vitro but did not facilitate its permeation through the skin.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

The study investigated the use of Transcutol-containing vesicles for the topical delivery of minoxidil. The results showed that the vesicles improved the skin penetration of minoxidil and increased its efficacy in promoting hair growth. The study suggests that transcutol-containing vesicles could be a promising approach for topical delivery of minoxidil for the treatment of hair loss. The vesicles were found to be stable and had good entrapment efficiency. However, the concentration of Transcutol affected the viscoelastic behavior of the vesicles and their ability to interact with the lipidic bilayer. Further research is needed to optimize the formulation of PEVs for the effective delivery of minoxidil.

View this study on tandfonline.com →

Discuss this study in the Community →

Research cited in this study

9 / 9 results

research Penetration Enhancer-Containing Vesicles as Carriers for Cutaneous Delivery of Minoxidil

128 citations , July 2009 in “International Journal of Pharmaceutics”

This study found that penetration enhancer-containing vesicles significantly improved minoxidil delivery to the skin compared to traditional liposomes and penetration enhancer-containing ethanolic solutions, with deformability linked to enhanced deposition.

research Formulation and In Vitro Assessment of Minoxidil Niosomes for Enhanced Skin Delivery

268 citations , April 2009 in “International Journal of Pharmaceutics”

In this study, niosomal formulations enhanced minoxidil skin accumulation compared to commercial and control solutions, suggesting a potential improvement for topical delivery in hair loss treatment.

research Liposomes And Niosomes As Potential Carriers For Dermal Delivery Of Minoxidil

85 citations , January 2007 in “Journal of Drug Targeting”

This study found that liposomal formulations improved minoxidil delivery to skin layers compared to niosomes and a control solution, suggesting enhanced potential for topical hair loss treatment.

research Effect of Ethosomal Minoxidil on Dermal Delivery and Hair Cycle of C57BL/6 Mice

23 citations , October 2006 in “Journal of Dermatological Science”

This review summarizes findings on the use of ethosomes for enhanced transdermal drug delivery and reports no new clinical results.

research Male Androgenetic Alopecia: Medical and Surgical Treatments

9 citations , February 2005 in “The Journal of Men's Health & Gender”

This article reviews treatment options for male androgenetic alopecia, including their distinct aims of arresting progression, stimulating regrowth, and concealing hair loss, and reports no new clinical results.

research Minoxidil: Mechanisms of Action on Hair Growth

397 citations , February 2004 in “British Journal of Dermatology”

This article reviews the mechanisms by which minoxidil stimulates hair growth and reports no new clinical findings.

A Randomized Clinical Trial of 5% Topical Minoxidil Versus 2% Topical Minoxidil and Placebo in the Treatment of Androgenetic Alopecia in Men

research A Randomized Clinical Trial of 5% Topical Minoxidil Versus 2% Topical Minoxidil and Placebo in the Treatment of Androgenetic Alopecia in Men

269 citations , August 2002 in “Journal of The American Academy of Dermatology”

This study found that 5% topical minoxidil significantly increased hair regrowth and improved psychosocial perceptions of hair loss in men with androgenetic alopecia compared to 2% topical minoxidil and placebo over 48 weeks.

research Allergic Contact Dermatitis to Topical Minoxidil Solution: Etiology and Treatment

123 citations , February 2002 in “Journal of The American Academy of Dermatology”

Minoxidil can cause skin allergy; use alternative solvents or treatments if allergic.

research Penetration of Minoxidil from Ethanol/Propylene Glycol Solutions: Effect of Application Volume and Occlusion

33 citations , June 1995 in “Journal of Pharmaceutical Sciences”

This study found that minoxidil penetration through the skin increased with higher ethanol content and occlusion, with the highest penetration observed at 90% ethanol.