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Glossary skin deposition

process where substances accumulate on or within skin layers

Skin deposition refers to the process by which substances, such as medications, pollutants, or cosmetic ingredients, settle and accumulate on the skin's surface or within its layers. This can impact skin health, either positively by delivering therapeutic agents or negatively by introducing harmful chemicals.

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Research

5 / 1000+ results

research Skin deposition and permeation of finasteridein vitro: effects of propylene glycol, ethanol and sodium lauryl sulfate

5 citations , August 2014 in “Pharmaceutical Development and Technology”

In this study, the researchers reported that while both propylene glycol and sodium lauryl sulfate enhanced finasteride's skin deposition, ethanol was the only effective enhancer of finasteride's permeation through the skin.

research Keratinocytes as Depository of Ammonium-Inducible Glutamine Synthetase: Age- and Anatomy-Dependent Distribution in Human and Rat Skin

14 citations , February 2009 in “PLoS ONE”

This study found that the enzyme glutamine synthetase is distributed throughout the epidermis and its activity in keratinocytes is notably increased by ammonium ions, suggesting the skin serves as a reservoir for glutamine generation.

research The Effect of Particle Size on the Deposition of Solid Lipid Nanoparticles in Different Skin Layers: A Histological Study.

71 citations , March 2016 in “PubMed”

This study found that sub-100 nm solid lipid nanoparticles showed the most effective skin penetration and depth, primarily via hair follicles, in rat skin evaluations.

research IMPROVED SKIN PENETRATION AND DEPOSITION OF NAFTIFINE FROM TRANSETHOSOMES AND TRANSETHOSOMAL GEL FORMULATIONS

12 citations , June 2022 in “FARMACIA”

This study found that a topical transethosomal system may enhance the skin penetration and deposition of naftifine compared to a marketed cream, potentially overcoming the stratum corneum barrier.

research The Effect of Particle Size on the Deposition of Solid Lipid Nanoparticles in Different Skin Layers: A Histological Study

128 citations , March 2016 in “Advanced Pharmaceutical Bulletin”

This study found that sub-100 nm size solid lipid nanoparticles showed the most effective skin penetration and depth, mainly via hair follicles, in rat skin.

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Community Join

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community microneedle, any long term users damage?

in Microneedling 35 upvotes 2 years ago

Microneedling is effective for hair growth, especially when combined with finasteride and minoxidil, but concerns exist about potential long-term skin damage. Users report increased collagen and elastin deposition, but the long-term effects on the scalp remain uncertain.

community Androgenetic alopecia is a skin disease: DHT-mediated skin disorders

63 upvotes 2 years ago

Dihydrotestosterone (DHT) impacts various skin conditions, including Androgenetic alopecia and seborrheic dermatitis, by causing overactivity in sebaceous glands. Topical medications Tacrolimus and Clobetasol can reduce these inflammatory conditions, and treatments like RU58841, Minoxidil, and Finasteride may also be beneficial.

community Why liposomal finasteride and minoxidil may be better than traditional topical solutions.

in Research/Science 2 upvotes 1 year ago

Liposomal formulations of finasteride and minoxidil may enhance drug delivery to the skin and hair follicles more effectively than traditional solutions, potentially improving treatment outcomes. However, more human clinical trials are needed to confirm these benefits.

community Finally Scalp Folliculitis-Free after 2 Decades of Suffering

64 upvotes 1 year ago

A 37-year-old male resolved scalp folliculitis by adopting a low-histamine diet and taking Vitamin A, Zinc, and Fish Oil, leading to better skin health and thicker hair. He warns about the potential toxicity of excessive Vitamin A intake.

community Crazy growth after adding ostrich oil + microneedling in 2 months. (already on treatment previously)

65 upvotes 4 weeks ago

The user experienced significant hair growth after adding ostrich oil and weekly microneedling to their existing treatment of topical dutasteride and minoxidil. They believe the combination of ostrich oil and microneedling contributed to the results, although some users suggest the increased microneedling frequency might be the main factor.

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Learn

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learn Microneedling

technique to create small wounds in skin to activate collagen production and hair growth

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn Melatonin

Can melatonin cause side effects on the skin or hair? Melatonin may cause hair loss or thinning in some users, but evidence is limited.

learn Scalp Micropigmentation

Does scalp micropigmentation work on all skin tones and hair colors? Scalp micropigmentation can be customized for various skin tones and hair colors.
Is scalp micropigmentation suitable for people with sensitive skin? Providers say scalp micropigmentation suits most skin types and describe patch tests, hypoallergenic pigments and a skin consultation for sensitive skin. These are provider claims rather than independent safety evidence, and pigment reactions remain a risk.

learn retinol

How does retinol improve scalp health and prepare the skin for other hair growth treatments? Retinol improves scalp health by promoting cellular turnover and reducing congestion.

learn Hyaluronic Acid

Does hyaluronic acid really hydrate the scalp, or is it mainly for skin care? Hyaluronic acid can hydrate the scalp, but its effectiveness may vary.

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Clinics

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Experts

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36
SMP Specialist
Noelle Skin
Nice, France

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Noelle Skin