TLDR The method accurately measures Tamsulosin and Finasteride in medication and is suitable for regular quality checks.
The document from 2012 detailed the development and validation of an RP-HPLC-PDA method for estimating Tamsulosin (TAM) and Finasteride (FIN) in bulk and tablet forms. The method demonstrated good linearity for TAM and FIN within specific concentration ranges and had low limits of detection (0.16µg/mL for TAM and 0.6µg/mL for FIN). The validation process, adhering to ICH guidelines, confirmed the method's precision, accuracy, specificity, robustness, and stability, with recovery rates near 100% for both drugs. The method was sensitive, reproducible, and reliable, with assay results for a commercial combination formulation showing 99.96% for TAM and 99.93% for FIN, aligning with label claims. It was deemed suitable for routine quality control tests and compatible with MS detection.
14 citations
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January 2011 in “Journal of analytical & bioanalytical techniques” Created accurate method to measure tamsulosin hydrochloride and finasteride in tablets.
5 citations
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January 2011 in “Der Pharmacia Lettre” The method accurately measures Finasteride and Tamsulosin in tablets without interference.
26 citations
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June 2010 in “Acta Pharmaceutica” Methods accurately measure tamsulosin hydrochloride and finasteride in combined dosages.
13 citations
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November 2006 in “E-journal of Chemistry” Found accurate way to measure finasteride in tablets.
22 citations
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September 2006 in “Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy” New method accurately measures finasteride in tablets.
27 citations
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July 2001 in “Journal of Pharmaceutical and Biomedical Analysis” Finasteride remains stable for two years with proper storage.
January 2015 in “INDONESIAN JOURNAL OF PHARMACY” A reliable method was developed to measure Tamsulosin and Finasteride in tablets accurately.
5 citations
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February 2014 in “Journal of Liquid Chromatography & Related Technologies” Method accurately measures finasteride and tamsulosin in combined drug form.
2 citations
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January 2012 in “Journal of The Chilean Chemical Society” New method accurately measures finasteride in tablets and bulk.
1 citations
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January 2012 in “Analytical chemistry, an Indian journal” A reliable method was developed to accurately measure tamsulosin hydrochloride and finasteride in tablets.
