HPTLC Method Validation for Simultaneous Determination of Tamsulosin Hydrochloride and Finasteride in Bulk and Pharmaceutical Dosage Form
April 2011
in “
Journal of analytical & bioanalytical techniques
”
TLDR Created accurate method to measure tamsulosin hydrochloride and finasteride in tablets.
The study developed and validated a TLC-densitometry method for the simultaneous determination of tamsulosin hydrochloride and finasteride in tablet dosage form. The method was found to be simple, precise, accurate, and selective, with a linearity range of 200-1200 ng/spot for tamsulosin hydrochloride and 1000-6000 ng/spot for finasteride. The accuracy of the method was assessed by percentage recovery and found to be 99.77 ± 0.71 % for tamsulosin hydrochloride and 99.75 ± 0.86 % for finasteride. The method can be used for routine analysis of tamsulosin hydrochloride and finasteride in tablet dosage form.
