13C-NMR Study of 4-Azasteroids in Solution and Solid State

    June 2002 in “ Steroids ”
    Jacek W. Morzycki, Iwona Wawer, Agnieszka Gryszkiewicz, Jadwiga Maj, Leszek Siergiejczyk, Alicja Zaworska
    TLDR 4-azasteroids, including finasteride, can inhibit 5α-reductase, helping treat conditions like enlarged prostate and hair loss.
    The study investigated 4-azasteroids, including finasteride, using 13C-NMR spectroscopy in both solution and solid states. It focused on the effects of substituents and steric factors of nitrogen atoms on chemical shifts of adjacent carbon atoms. The research confirmed the polymorphism of finasteride and identified a new molecular complex with dioxane. The study highlighted the potential of 4-azasteroids as 5α-reductase inhibitors, which are relevant in treating conditions like benign prostatic hypertrophy and male pattern baldness. The findings provided insights into the structural features and biological activity of these compounds.
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