Caffeic Acid N-[3,5-Bis(Trifluoromethyl)Phenyl] Amide as a Non-Steroidal Inhibitor for Steroid 5α-Reductase Type 1 Using a Human Keratinocyte Cell-Based Assay and Molecular Dynamics

    December 2022 in “ Scientific Reports ”
    Aye Chan Khine Lin, Ponsawan Netcharoensirisuk, Kamonpan Sanachai … Supakarn Chamni
    Studysummary This study found that caffeic acid amide derivative, compound 4, effectively inhibited steroid 5α-reductase type 1 in vitro, suggesting potential for development as a treatment for androgenic alopecia.
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