Caffeic Acid N-[3,5-Bis(Trifluoromethyl)Phenyl] Amide as a Non-Steroidal Inhibitor for Steroid 5α-Reductase Type 1 Using a Human Keratinocyte Cell-Based Assay and Molecular Dynamics

December 2022 in “ Scientific Reports ”

Aye Chan Khine Lin, Ponsawan Netcharoensirisuk, Kamonpan Sanachai, Warongrit Sukma, Chaisak Chansriniyom, Chatchai Chaotham, Wanchai De-Eknamkul, Thanyada Rungrotmongkol, Supakarn Chamni

caffeic acid N-[3,5-bis(trifluoromethyl)phenyl] amide steroid 5α-reductase type 1 SRD5A1 androgenic alopecia human keratinocyte cells HaCaT cells avicequinone C finasteride dutasteride molecular dynamics simulations dihydrotestosterone DHT compound 4 Propecia Avodart

From the encyclopedia

Finasteride →

Frontline, gold standard treatment for combatting androgenic alopecia

Dutasteride →

Heavy duty finasteride that comes with higher risks

Studysummary This study found that caffeic acid amide derivative, compound 4, effectively inhibited steroid 5α-reductase type 1 in vitro, suggesting potential for development as a treatment for androgenic alopecia.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer

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research 5-Alpha Reductase Inhibitors in Androgenetic Alopecia: Shifting Paradigms, Current Concepts, Comparative Efficacy, and Safety

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This review found that dutasteride is more potent than finasteride as a dual receptor dihydrotestosterone blocker for treating androgenetic alopecia and shares a similar safety profile in terms of fertility, teratogenicity, neurotoxicity, and hepatotoxicity.

research Female Androgenetic Alopecia: An Update on Diagnosis and Management

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The Efficacy and Safety of Dutasteride Compared with Finasteride in Treating Men with Androgenetic Alopecia: A Systematic Review and Meta-Analysis

research The Efficacy and Safety of Dutasteride Compared with Finasteride in Treating Men with Androgenetic Alopecia: A Systematic Review and Meta-Analysis

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research Discovery of Natural Steroid 5 Alpha-Reductase Inhibitors

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This review highlights the challenges in screening for steroid 5 alpha-reductase inhibitors and discusses significant variability in the effectiveness of finasteride and dutasteride, calling for standardized testing methods to develop safer, more specific inhibitors from herbal preparations.

research Anti-Androgenic Curcumin Analogues as Steroid 5-Alpha Reductase Inhibitors

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research Synthesis, Biological Evaluation and Molecular Docking of Avicequinone C Analogues as Potential Steroid 5α-Reductase Inhibitors

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This study found that a synthetic avicequinone C analogue, 5e, was significantly more potent in inhibiting steroid 5α-reductase type 1 activity in human keratinocytes compared to the original isolated compound.

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research Identification of a New Plant Extract for Androgenic Alopecia Treatment Using a Non-Radioactive Human Hair Dermal Papilla Cell-Based Assay

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research Androgenetic Alopecia: An Evidence-Based Treatment Update

151 citations , May 2014 in “American Journal of Clinical Dermatology”

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186 citations , December 2011 in “Molecules”

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research Inhibitory Activities of Puerariae Flos Against Testosterone 5α-Reductase and Its Hair Growth Promotion Activities

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research An Overview on 5α-Reductase Inhibitors

219 citations , October 2009 in “Steroids”

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research Testosterone 5-Alpha-Reductase Inhibitory Active Constituents of Piper Nigrum Leaf

44 citations , January 2007 in “Biological & pharmaceutical bulletin”

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research New 5α-Reductase Inhibitors: In Vitro and In Vivo Effects

45 citations , February 2005 in “Steroids”

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