Enzymes

March 2008 in “ British Journal of Pharmacology ”

S P H Alexander, A Mathie, J A Peters

TLDR Enzymes play crucial roles in metabolism, health, and disease management.

The document provided an overview of various enzymes, including adenosine metabolizing enzymes, adenylyl cyclases, amino acid hydroxylases, cyclooxygenases, N-acylethanolamine acid amidase, inositol monophosphatase, lipoxygenases, nitric oxide synthases, phospholipase D, phospholipase A2, phosphoinositide-specific phospholipase C, and protein kinases. It detailed their functions, regulatory mechanisms, inhibitors, and potential therapeutic implications. Specific enzymes like adenylyl cyclases were categorized based on calcium sensitivity, while cyclooxygenases were noted for their role in prostaglandin synthesis and inhibition by NSAIDs. The document also highlighted the pharmacological complexities and provided references for further reading on these biochemical pathways.

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