A Definitive Role of Ornithine Decarboxylase in Photocarcinogenesis

    September 2001 in “ American Journal Of Pathology ”
    Nihal Ahmad, Anita C. Gilliam, Santosh K. Katiyar, Thomas G. O’Brien, Hasan Mukhtar
    TLDR Inhibiting ODC can prevent UV-induced skin cancer.
    The study from September 2001 demonstrated that ornithine decarboxylase (ODC) played a crucial role in UVB-induced skin carcinogenesis. Using K5/ODC transgenic mice, researchers found that UVB exposure significantly increased ODC activity, leading to the development of epidermal tumors in 40% of the mice, while nontransgenic mice did not develop tumors. The study concluded that inhibiting ODC with α-difluoromethylornithine (DFMO) completely prevented tumor formation, suggesting that ODC inhibitors could be a potential therapeutic strategy for preventing UV-induced skin cancer.
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