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GlossaryVaniqa (DFMO)

topical cream that slows facial hair growth in women

Vaniqa is a topical cream containing eflornithine hydrochloride, used to reduce unwanted facial hair in women. It works by inhibiting an enzyme involved in hair growth, thereby slowing down the rate of hair production.

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research Biochemical Features of Primary Cells from a Pediatric Patient with a Gain-of-Function ODC1 Genetic Mutation

15 citations, June 2019 in “Biochemical Journal”

A new genetic disorder caused by an ODC1 mutation can be treated with DFMO.

research Alpha-Difluoromethylornithine, a Polyamine Inhibitor: Its Potential Role in Controlling Hair Growth and in Cancer Treatment and Chemoprevention

9 citations, April 2006 in “International Journal of Dermatology”

DFMO may help control hair growth and treat cancer.

research Bachmann–Bupp Syndrome and Treatment

July 2023 in “Developmental medicine and child neurology/Developmental medicine & child neurology”

DFMO treatment improves hair growth, muscle tone, and development in Bachmann-Bupp syndrome patients.

research Co-Operation Between Follicular Ornithine Decarboxylase and v-Ha-ras Induces Spontaneous Papillomas and Malignant Conversion in Transgenic Skin

88 citations, August 1998 in “Carcinogenesis”

High levels of ODC and a mutant Ha-ras gene cause tumors in mice.

research A Definitive Role of Ornithine Decarboxylase in Photocarcinogenesis

67 citations, September 2001 in “American Journal Of Pathology”

Inhibiting ODC can prevent UV-induced skin cancer.

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