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    Selective Non-Steroidal Inhibitors of 5α-Reductase Type 1

    January 2004 in “ Journal of steroid biochemistry and molecular biology/˜The œJournal of steroid biochemistry and molecular biology ”
    Ernesto G. Occhiato, Antonio Guarna, Giovanna Danza, Mario Serio
    Studysummary This review discusses the development and selectivity of 5 alpha-reductase inhibitors, particularly non-steroidal ones, and reports no new clinical trial results.
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    Research cited in this study 18

    1. Use of Cyproterone Acetate, Finasteride, and Spironolactone to Treat Idiopathic Hirsutism Fertility and Sterility · 2003
    2. Cutaneous Androgen Metabolism: Basic Research And Clinical Perspectives ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2002
    3. Journal Review: Long-Term (5-Year) Multinational Experience with Finasteride 1mg in the Treatment of Men with Androgenetic Alopecia Hair transplant forum international · 2002
    4. Effect of C-Ring Modifications in Benzo[c]quinolizin-3-ones, New Selective Inhibitors of Human 5α-Reductase 1 Bioorganic & Medicinal Chemistry · 2001
    5. Sebocytes Are the Key Regulators of Androgen Homeostasis in Human Skin ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2001
    6. Benzo[c]quinolizin-3-ones: A Novel Class of Potent and Selective Nonsteroidal Inhibitors of Human Steroid 5α-Reductase 1 Journal of Medicinal Chemistry · 2000
    7. The Hair Follicle: A Paradoxical Androgen Target Organ Hormone Research in Paediatrics · 2000
    8. Expression of mRNA for Androgen Receptor, 5α-Reductase, and 17β-Hydroxysteroid Dehydrogenase in Human Dermal Papilla Cells British journal of dermatology/British journal of dermatology, Supplement · 1999
    9. Immunohistochemical Localization of Types 1 and 2 5α-Reductase in Human Scalp British Journal of Dermatology · 1999
    10. Finasteride Drugs · 1999
    11. Cloning, Expression, and Characterization of Rhesus Macaque Types 1 and 2 5alpha-Reductase: Evidence for Mechanism-Based Inhibition by Finasteride The Journal of Steroid Biochemistry and Molecular Biology · 1998
    12. 5α-Reductase Inhibitors: Chemical and Clinical Models Steroids · 1998
    13. Synthesis and 5α-Reductase Inhibitory Activity of 8-Substituted Benzo[ƒ]Quinolinones Derived from Palladium Mediated Coupling Reactions Bioorganic & Medicinal Chemistry Letters · 1998
    14. Mechanism-Based Inhibition of Human Steroid 5α-Reductase by Finasteride: Enzyme-Catalyzed Formation of NADP-Dihydrofinasteride, a Potent Bisubstrate Analog Inhibitor Journal of the American Chemical Society · 1996
    15. The Enzyme and Inhibitors of 4-Ene-3-Oxosteroid 5α-Oxidoreductase Steroids · 1995
    16. Synthesis of Phenanthridin-3-One Derivatives: Non-Steroidal Inhibitors of Steroid 5-Alpha-Reductase Tetrahedron Letters · 1995
    17. Finasteride The New England Journal of Medicine · 1994
    18. Nonsteroidal Inhibitors of Human Type I Steroid 5α-Reductase Journal of Medicinal Chemistry · 1993

    Related research 7

    1. Untargeted Metabolomics and Steroid Signatures in Urine of Male Pattern Baldness Patients After Finasteride Treatment for a Year Journal of The American Academy of Dermatology · 2021
    2. 5-Alpha Reductase Inhibitors in Androgenetic Alopecia: Shifting Paradigms, Current Concepts, Comparative Efficacy, and Safety Dermatologic Therapy · 2020
    3. A Review on Finasteride: A 5-Alpha Reductase Inhibitor, Its Mechanism, Facts, and Benefits Journal of Drug Delivery and Therapeutics · 2019
    4. The Effects of Finasteride on Scalp Skin and Serum Androgen Levels in Men with Androgenetic Alopecia Journal of The American Academy of Dermatology · 1999
    5. A Model for the Turnover of Dihydrotestosterone in the Presence of the Irreversible 5α-Reductase Inhibitors GI198745 and Finasteride Clinical Pharmacology & Therapeutics · 1998
    6. Effect of MK-386, a Novel Inhibitor of Type 1 5 Alpha-Reductase, Alone and in Combination with Finasteride, on Serum Dihydrotestosterone Concentrations in Men The Journal of Clinical Endocrinology and Metabolism · 1996
    7. The Effect of Finasteride, a 5 Alpha-Reductase Inhibitor, on Scalp Skin Testosterone and Dihydrotestosterone Concentrations in Patients With Male Pattern Baldness The Journal of Clinical Endocrinology and Metabolism · 1994