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    Effect of C-Ring Modifications in Benzo[c]quinolizin-3-ones, New Selective Inhibitors of Human 5α-Reductase 1

    June 2001 in “ Bioorganic & Medicinal Chemistry ”
    Antonio Guarna, Ernesto G. Occhiato, Fabrizio Machetti … Mario Serio
    Studysummary This study found that octahydrobenzo[c]quinolizin-3-one derivatives, particularly compound 3, were potent and selective inhibitors of the enzyme 5α-reductase type 1.
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    Research cited in this study 8

    1. Benzo[c]quinolizin-3-ones: A Novel Class of Potent and Selective Nonsteroidal Inhibitors of Human Steroid 5α-Reductase 1 Journal of Medicinal Chemistry · 2000
    2. Treatment of Hair Loss The New England Journal of Medicine · 1999
    3. The Enzyme and Inhibitors of 4-Ene-3-Oxosteroid 5α-Oxidoreductase Steroids · 1995
    4. Synthesis of Phenanthridin-3-One Derivatives: Non-Steroidal Inhibitors of Steroid 5-Alpha-Reductase Tetrahedron Letters · 1995
    5. The Effect of Finasteride, a 5 Alpha-Reductase Inhibitor, on Scalp Skin Testosterone and Dihydrotestosterone Concentrations in Patients With Male Pattern Baldness The Journal of Clinical Endocrinology and Metabolism · 1994
    6. Nonsteroidal Inhibitors of Human Type I Steroid 5α-Reductase Journal of Medicinal Chemistry · 1993
    7. Chapter 20: Pathogenesis and Treatment of Alopecias Annual Reports in Medicinal Chemistry · 1989
    8. Treatment of Hirsutism with 5α-Reductase Inhibitors Clinics in endocrinology and metabolism · 1986

    Related research 1

    1. Effect of C-Ring Modifications in Benzo[c]quinolizin-3-ones, New Selective Inhibitors of Human 5α-Reductase 1 Bioorganic & Medicinal Chemistry · 2001