Benzo[c]quinolizin-3-ones: A Novel Class of Potent and Selective Nonsteroidal Inhibitors of Human Steroid 5α-Reductase 1

    September 2000 in “ Journal of Medicinal Chemistry ”
    Antonio Guarna, Fabrizio Machetti, Ernesto G. Occhiato, Dina Scarpi, Alessandra Comerci, Giovanna Danza, Rosa Mancina, Mario Serio, K. G. Hardy
    Image of study
    TLDR Benzo[c]quinolizin-3-ones are effective nonsteroidal inhibitors of human steroid 5α-reductase 1.
    The study focused on the stereochemical assignments of benzo[c]quinolizin-3-ones, a novel class of nonsteroidal inhibitors of human steroid 5α-reductase 1. The researchers used semi-empirical AMI studies and ¹H NMR spectroscopy to determine the relative stereochemistry of these compounds. They found that the nitrogen atom in these compounds exhibited an intermediate hybridization between sp² and sp³, influencing the chair-like conformation of the A ring. The stereochemistry of various methyl-substituted derivatives was assigned based on coupling constant values and chemical shifts observed in the NMR spectra. The findings provided insights into the structural characteristics necessary for the inhibitory activity of these compounds.
    Discuss this study in the Community →

    Research cited in this study

    6 / 6 results

    Related Community Posts Join

    6 / 31 results

      community Ranking the best treatments for hair growth

      in Research/Science  3 upvotes 4 days ago
      Effective hair growth treatments include finasteride, minoxidil, dutasteride, and hair transplants, with additional options like microneedling, low-level laser therapy, and PRP showing some benefits. Newer treatments such as GHK-Cu peptides and ketoconazole shampoo are promising, while others like saw palmetto and biotin are less effective unless deficiencies exist.

      community What to do if fin is still not working after 2.5 years

      in Finasteride/Dutasteride  22 upvotes 8 months ago
      The user is experiencing increased hair loss despite using finasteride and oral minoxidil and is hesitant to switch to dutasteride due to side effects and family planning concerns. Alternatives suggested include dutasteride, microneedling, and addressing stress or nutrient deficiencies.

      community 2.5 years Minoxidil and HRT, CPA->Lupron +Minox 5%

      in Transgender  611 upvotes 1 year ago
      The user experienced significant hair regrowth after 2.5 years of using Minoxidil 5% and hormone replacement therapy (HRT) with Lupron, despite initial scalp irritation. Finasteride was ineffective for them.

      community How to reduce cortisol (stress hormone) naturally?

      in Chat  38 upvotes 3 years ago
      The conversation discusses natural ways to reduce cortisol, such as avoiding caffeine, getting proper sleep, syncing with the sun, walking in nature, breathing exercises, increasing calories, and not doing keto. Magnesium supplements are recommended for stress reduction.

      community Do 'do it yourself' topical fin really work?

      in Treatment  1 upvotes 6 months ago
      DIY topical finasteride mixed with minoxidil is used due to the unavailability of pharmacy-grade options in Sweden. The user reports positive results after three months, with improved hair growth at the temples and vertex.

    Related Research

    1 / 1 results