The Enzyme and Inhibitors of 4-Ene-3-Oxosteroid 5α-Oxidoreductase

June 1995 in “ Steroids ”

Xun Li, Cailin Chen, S. M. Singh, Fernand Labire

5 alpha-reductase DHT 5 alpha-dihydrotestosterone androgen-related disorders male pattern baldness 5 alpha-reductase inhibitors nonsteroidal compounds steroidal compounds DHT male pattern baldness

TLDR Inhibitors of the enzyme 5 alpha-reductase could potentially treat disorders like prostate cancer and baldness.

The document reviewed the enzyme 5α-reductase, which converts testosterone to 5α-dihydrotestosterone (DHT) and is implicated in various androgen-related disorders such as prostate cancer, benign prostatic hyperplasia, acne, female hirsutism, and male pattern baldness. It discussed the enzyme's biological functions, purification, and characterization, as well as the synthesis and evaluation of various inhibitors. The review highlighted the importance of 5α-reductase inhibitors in treating these conditions and compared the IC50 and Ki values of different compounds. The document served as a comprehensive reference for past research and future challenges in the field.

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Research cited in this study

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research Azasteroids as Inhibitors of Testosterone 5α-Reductase in Mammalian Skin

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Certain 4-azasteroids are effective at blocking the enzyme that processes testosterone in human skin and could help treat acne, excessive hair growth, and male pattern baldness.

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New compounds called benzoquinolinones may treat conditions linked to excess DHT.

research Structure of Human Type II 5 Alpha-Reductase Gene

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The human type II 5α-reductase gene has a specific structure important for understanding certain medical conditions.

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Finasteride safely lowers DHT levels without affecting testosterone.

research Species Differences in Prostatic Steroid 5α-Reductases of Rat, Dog, and Human

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Different animals have unique versions of the enzyme that changes testosterone into another hormone, which is important for creating effective treatments for prostate and hair loss conditions.

research The Antiandrogenic Action of 4-Androsten-3-One-17β-Carboxylic Acid and Its Methyl Ester on Hamster Flank Organ

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The chemicals 17βC and its methyl ester can block the effects of testosterone on hamster skin but not the effects of DHT.

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community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

nkrata in Research 830 upvotes 1 year ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community risks with finasteride and dutasteride

in Research/Science 143 upvotes 8 months ago

Finasteride and dutasteride have potential risks, including post-finasteride syndrome, but are commonly used for hair loss. RU58841, minoxidil, and needling are suggested as alternatives, though all treatments carry risks.

community Androgenetic alopecia is a skin disease: DHT-mediated skin disorders

in Research/Science 63 upvotes 2 years ago

Dihydrotestosterone (DHT) impacts various skin conditions, including Androgenetic alopecia and seborrheic dermatitis, by causing overactivity in sebaceous glands. Topical medications Tacrolimus and Clobetasol can reduce these inflammatory conditions, and treatments like RU58841, Minoxidil, and Finasteride may also be beneficial.

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