The Enzyme and Inhibitors of 4-Ene-3-Oxosteroid 5α-Oxidoreductase

    June 1995 in “ Steroids ”
    Xun Li, Cailin Chen, S. M. Singh, Fernand Labire
    TLDR Inhibitors of the enzyme 5 alpha-reductase could potentially treat disorders like prostate cancer and baldness.
    The document reviewed the enzyme 5α-reductase, which converts testosterone to 5α-dihydrotestosterone (DHT) and is implicated in various androgen-related disorders such as prostate cancer, benign prostatic hyperplasia, acne, female hirsutism, and male pattern baldness. It discussed the enzyme's biological functions, purification, and characterization, as well as the synthesis and evaluation of various inhibitors. The review highlighted the importance of 5α-reductase inhibitors in treating these conditions and compared the IC50 and Ki values of different compounds. The document served as a comprehensive reference for past research and future challenges in the field.
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