A Model for the Turnover of Dihydrotestosterone in the Presence of the Irreversible 5α-Reductase Inhibitors GI198745 and Finasteride

    Per Olsson Gisleskog, David S. Hermann, Margareta Hammarlund-Udenaes, Mats O. Karlsson
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    TLDR Both drugs lower DHT levels, with GI198745 being more effective.
    This document presents a model for the turnover of dihydrotestosterone (DHT) in the presence of two 5α-reductase inhibitors, GI198745 and finasteride. The study found that both drugs can lower DHT levels, with GI198745 being more effective due to its greater potency and longer half-life. The model accurately predicted the rates of DHT in healthy men who were given the drugs. The study proposes a model for understanding DHT turnover in the presence of these drugs, which can be useful in treating conditions related to DHT, such as hair loss and benign prostatic hyperplasia.
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