49 citations
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January 2004 in “Journal of steroid biochemistry and molecular biology/The Journal of steroid biochemistry and molecular biology”
This review discusses the development and selectivity of 5alpha-reductase inhibitors, particularly non-steroidal ones, and reports no new clinical trial results.
11 citations
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May 1996 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism”
This study reported that 5alpha-reductase type 2 is the predominant enzyme in pubic skin fibroblasts across normal men, women, and hirsute patients, suggesting potential treatment options for idiopathic hirsutism.
This study will explore whether combination therapy with either dutasteride or finasteride and an α1 blocker is more effective than monotherapy for treating BPH, but it reports no new results.
1 citations
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January 2004 in “Linchuang pifuke zazhi”
This case report describes a 23-year-old man experiencing painful gynecomastia aggravated by low dose finasteride for androgenetic alopecia, which reversed after stopping the medication.
An 18-year-old is using a high-dose treatment for hair loss, including 2.5 mg dutasteride, topical minoxidil, and injectable GHK-Cu, despite minimal hair loss. Many users suggest reducing the dutasteride dose due to potential side effects and recommend starting with finasteride instead.
The user started with oral minoxidil and switched to 2.5mg dutasteride, experiencing significant hair growth without side effects. They believe dutasteride has fewer side effects than finasteride due to its action on both type 1 and 2 5-alpha reductase enzymes.
The user achieved significant hair regrowth using topical 5% minoxidil and oral 1mg finasteride daily, especially around the temples. They experienced minimal side effects, with initial difficulty maintaining erections that resolved after a few weeks.
Creatine may temporarily increase testosterone but likely has minimal impact on hair loss, especially when using 5-alpha reductase inhibitors like finasteride. Some users stopped creatine due to hair loss concerns, but results are unclear due to concurrent use of treatments like topical finasteride and microneedling.
The conversation discusses the effectiveness of dutasteride and finasteride for hair loss, with the original poster expressing concern over worsening hair loss despite long-term use. Users suggest that if no improvement is seen after 12-18 months, it may be time to reconsider the treatment, and some question the possibility of other underlying causes or the quality of the medication.