Expression of mRNA for Androgen Receptor, 5α-Reductase, and 17β-Hydroxysteroid Dehydrogenase in Human Dermal Papilla Cells
November 1999
in “
British journal of dermatology/British journal of dermatology, Supplement
”
androgen receptor 5alpha-reductase 17beta-hydroxysteroid dehydrogenase dermal papilla cells AR mRNA type I 5alpha-reductase type II 5alpha-reductase type II 17beta-HSD type III 17beta-HSD outer root sheath cells androgens site-specific sensitivity androgen receptor 5-alpha reductase 17-beta HSD DPCs AR mRNA type I 5-alpha reductase type II 5-alpha reductase type II 17-beta HSD type III 17-beta HSD outer root sheath cells androgens site-specific sensitivity
TLDR Hair sensitivity to androgens is partly controlled by specific enzyme expressions in different hair areas.
The study demonstrated that the sensitivity of hair to androgens was partially controlled by the site-specific expression of androgen receptor (AR), 5α-reductase, and 17β-hydroxysteroid dehydrogenase (17β-HSD) in dermal papilla cells (DPCs). AR mRNA was found in beard and axillary hair DPCs but only at low levels in occipital scalp hair DPCs. Type I 5α-reductase mRNA was present in all DPCs, while type II 5α-reductase mRNA was only in beard DPCs. Type II 17β-HSD mRNA was strongly expressed in outer root sheath cells but not in most DPCs, except for male axillary DPCs. Type III 17β-HSD mRNA was expressed in beard and axillary DPCs from both sexes and was not regulated by androgen. These findings suggested a role for these enzymes in the site-specific sensitivity of hair to androgens.
