Expression of mRNA for Androgen Receptor, 5α-Reductase, and 17β-Hydroxysteroid Dehydrogenase in Human Dermal Papilla Cells

    November 1999 in “ British journal of dermatology/British journal of dermatology, Supplement ”
    Yumiko Ando, Yuji Yamaguchi, K. Hamada, Kunihiko Yoshikawa, Satoshi Itami
    Image of study
    TLDR Hair sensitivity to androgens is partly controlled by specific enzyme expressions in different hair areas.
    The study demonstrated that the sensitivity of hair to androgens was partially controlled by the site-specific expression of androgen receptor (AR), 5α-reductase, and 17β-hydroxysteroid dehydrogenase (17β-HSD) in dermal papilla cells (DPCs). AR mRNA was found in beard and axillary hair DPCs but only at low levels in occipital scalp hair DPCs. Type I 5α-reductase mRNA was present in all DPCs, while type II 5α-reductase mRNA was only in beard DPCs. Type II 17β-HSD mRNA was strongly expressed in outer root sheath cells but not in most DPCs, except for male axillary DPCs. Type III 17β-HSD mRNA was expressed in beard and axillary DPCs from both sexes and was not regulated by androgen. These findings suggested a role for these enzymes in the site-specific sensitivity of hair to androgens.
    Discuss this study in the Community →

    Research cited in this study

    5 / 5 results

    Related Community Posts Join

    6 / 1000+ results

      community Creatine's effect on Hair Loss and DHT

      in Research/Science  100 upvotes 2 years ago
      A 21-year-old male managed to control his hair loss using Nizoral, RU58841, and finasteride, but experienced increased scalp itchiness after starting creatine, which subsided upon stopping creatine. Users shared mixed experiences on whether creatine affects hair loss, with some reporting negative effects and others seeing no change or defending its benefits.

      community How is dht not beneficial to you?

      in Finasteride/Dutasteride  111 upvotes 1 month ago
      DHT is important for sexual function and mood, but finasteride and dutasteride can reduce DHT, causing side effects like reduced libido and erectile dysfunction. These treatments are effective for hair loss, but their impact on DHT leads to debate.

      community Hair loss causes are still a myth.

      in Chat  17 upvotes 4 years ago
      The conversation discusses the complexity of hair loss causes, suggesting that DHT sensitivity alone doesn't fully explain it. Treatments mentioned include finasteride and dutasteride.

      community Natural Remedies: Polyphenols and Hair Loss

       20 upvotes 6 years ago
      Natural remedies to treat hair loss, such as polyphenols, apple peel extract, grape seed extract, green tea extract, peppermint oil, pumpkin seed oil, apigenin, Ginkgo biloba, red clover extract, olive leaf extract, Ecklonia Cava and Grateloupia elliptica. In addition, terpenes, carotenoids, and tocopherols were discussed as potential treatments.

      community A hair model who does beauty ads and has 3 million followers claims he went from almost a Norwood 3 to a perfect hairline in 8 months on only Minoxidil and Rosemary oil. Curious, what are people’s thoughts?

      in Chat 3 years ago
      This conversation discusses the results of a model who claims he went from almost a Norwood 3 to a perfect hairline in 8 months using only Minoxidil and Rosemary oil. The replies suggest that this could be realistic but long-term results would require additional treatments like finasteride or other medications to prevent further hair loss.

      community Ru58841 ruined my life. Here’s why.

      in Product  130 upvotes 3 years ago
      User experienced shortness of breath, high blood pressure, red eyes, and eye floaters after using RU58841 for hair loss. They warn others to avoid RU58841 and stick to finasteride, minoxidil, and dutasteride.

    Related Research

    7 / 7 results