Screening Compounds From Indonesian Spices Against MMP9 And TNFα As Targets For Diabetic Wound Healing Using Molecular Docking

The study investigates the potential of Indonesian spices in wound healing for diabetes by targeting MMP9 and TNFα, which are involved in chronic wound formation. Using in silico molecular docking, 106 compounds were screened, and 4 compounds—hinokinin, procyanidin, xanthorrhizol, cubebin, and rosmarinic acid—showed potential to inhibit both proteins. Procyanidin emerged as the most promising candidate, with lower binding energy than native ligands for MMP9 and TNFα (-9.2 and -9.1 kcal/mol, respectively) and Ki values of 0.180 μM and 0.213 μM, suggesting its potential as a therapeutic agent for diabetic wound healing.