Identification of a New Plant Extract for Androgenic Alopecia Treatment Using a Non-Radioactive Human Hair Dermal Papilla Cell-Based Assay

    Ruchy Jain, Orawan Monthakantirat, Parkpoom Tengamnuay, Wanchai De-Eknamkul
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    TLDR A new plant extract from Avicennia marina could potentially be used to treat common hair loss.
    In 2015, Jain et al. conducted a study testing 30 plant extracts for their ability to inhibit the 5α-reductase type 1 (5a-R1) enzyme, which is linked to androgenic alopecia (AGA), a common type of hair loss. The extract from Avicennia marina (AM) showed the highest inhibitory activity, reducing the production of 5α-DHT, a hormone associated with hair loss, by 52% at a concentration of 10 µg/ml. The cells treated with this concentration of AM showed 100.5 ± 2.02% viability, indicating a positive effect of the AM extract. The study concluded that Avicennia marina could potentially be used for the treatment of AGA.
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