Identification of a New Plant Extract for Androgenic Alopecia Treatment Using a Non-Radioactive Human Hair Dermal Papilla Cell-Based Assay

    December 2015 in “ BMC Complementary and Alternative Medicine ”
    Ruchy Jain, Orawan Monthakantirat, Parkpoom Tengamnuay, Wanchai De-Eknamkul
    Image of study
    TLDR A new plant extract from Avicennia marina could potentially be used to treat common hair loss.
    In 2015, Jain et al. conducted a study testing 30 plant extracts for their ability to inhibit the 5α-reductase type 1 (5a-R1) enzyme, which is linked to androgenic alopecia (AGA), a common type of hair loss. The extract from Avicennia marina (AM) showed the highest inhibitory activity, reducing the production of 5α-DHT, a hormone associated with hair loss, by 52% at a concentration of 10 µg/ml. The cells treated with this concentration of AM showed 100.5 ± 2.02% viability, indicating a positive effect of the AM extract. The study concluded that Avicennia marina could potentially be used for the treatment of AGA.
    Discuss this study in the Community →

    Research cited in this study

    23 / 23 results

    Related Community Posts Join

    6 / 1000+ results

      community A hill on which I will die: The DHT itch absolutely exists

      in Research/Science  209 upvotes 6 months ago
      The DHT itch is linked to hair loss and persists despite finasteride use; switching to dutasteride helped alleviate the itch and promoted regrowth. Some users suggest seborrheic dermatitis as a cause and recommend treatments like medicated shampoos, vitamin D, and minoxidil.
      FCE 28260: A Forgotten 5α-Reductase Inhibitor

      community FCE 28260: A Forgotten 5α-Reductase Inhibitor

      in Research  330 upvotes 2 months ago
      FCE 28260 (PNU 156765), an under-explored 5α-reductase inhibitor, showcases promising results in research by Giudici et al., outperforming well-known treatments like Finasteride in reducing the conversion of testosterone to DHT. Its superior efficacy, demonstrated through lower IC50 values in both natural and human recombinant enzyme studies, suggests it could offer more effective management of DHT-related conditions. Additionally, its lower molecular weight hints at better potential for topical application, potentially offering advantages in treating conditions such as androgenic alopecia. Despite its potential, it has not advanced in development, possibly due to financial limitations, leaving its therapeutic prospects and side effect profile largely unexplored.

      community DHT and 5AR respect post, it's importance within the brain

      in Research/Science  111 upvotes 8 months ago
      The conversation discusses whether to use finasteride for hair loss, considering its role in inhibiting DHT and 5AR, which can affect brain function and mood. Some users report anxiety and depression from finasteride, while others do not experience these side effects and emphasize the importance of DHT for brain and prostate health.

      community DHT/Testosterone levels in scalp Fin VS Dut.

      in Finasteride/Dutasteride  60 upvotes 4 months ago
      Dutasteride raises scalp testosterone by 99%, which may not be ideal for those sensitive to all androgens. Some argue finasteride's balancing act might be better, while others believe dutasteride is superior for hair regrowth.

      community Having androgen receptor density and sensitivity at wrong f*ing place

      in Satire  7 upvotes 1 month ago
      The conversation discusses hair loss treatments, focusing on the use of topical minoxidil, microneedling, finasteride, and dutasteride, while debating the role of testosterone and DHT in hair loss. It also touches on the potential liver health impacts of these treatments and the genetic sensitivity of hair follicles to androgens.

    Related Research

    4 / 4 results