Testosterone 5-Alpha-Reductase Inhibitory Active Constituents of Piper Nigrum Leaf

January 2007 in “ Biological & pharmaceutical bulletin ”

Noriko Hirata, Masashi Tokunaga, Shunsuke Naruto, Munekazu Iinuma, Hideaki Matsuda

testosterone 5α-reductase Piper nigrum Piper cubeba cubebin 3,4-dimethoxy-3,4-desmethylenedioxycubebin piperine anti-androgenic hair regrowth testosterone-sensitive black pepper cubeb pepper

TLDR Black pepper leaf extract contains compounds that can block testosterone effects and promote hair growth.

In a study from 2007, researchers found that aqueous ethanolic extracts from the leaves and fruits of Piper nigrum, as well as fruits from Piper cubeba, exhibited potent testosterone 5α-reductase inhibitory activity, which is relevant for the development of cosmetic hair-care agents. The active constituents responsible for this activity were identified as (−)-cubebin (1) and (−)-3,4-dimethoxy-3,4-desmethylenedioxycubebin (2) from P. nigrum leaf extract, and piperine from P. nigrum fruit. These compounds were shown to inhibit 5α-reductase for the first time. Additionally, the P. nigrum leaf extract demonstrated anti-androgenic activity in vivo, as evidenced by a hair regrowth assay in testosterone-sensitive male C57Black/6CrSlc strain mice.

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Anti-Androgenic and Hair Growth Promoting Activities of Lygodii Spora (Spore of Lygodium Japonicum): Active Constituents Inhibiting Testosterone 5α-Reductase

research Anti-Androgenic and Hair Growth Promoting Activities of Lygodii Spora (Spore of Lygodium Japonicum): Active Constituents Inhibiting Testosterone 5α-Reductase

38 citations , January 2002 in “Biological & Pharmaceutical Bulletin”

Lygodii Spora extract may help treat hair loss by blocking a hair loss-related enzyme and promoting hair growth.

research Anti-Androgenic Activity of Myricae Cortex: Isolation of Active Constituents from Bark of Myrica Rubra

51 citations , January 2001 in “Biological & Pharmaceutical Bulletin”

The bark of Myrica rubra contains compounds that can block testosterone effects and might help prevent hair loss.

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