Testosterone 5-Alpha-Reductase Inhibitory Active Constituents of Piper Nigrum Leaf

January 2007 in “ Biological & pharmaceutical bulletin ”

Noriko Hirata, Masashi Tokunaga, Shunsuke Naruto, Munekazu Iinuma, Hideaki Matsuda

testosterone 5α-reductase Piper nigrum Piper cubeba cubebin 3,4-dimethoxy-3,4-desmethylenedioxycubebin piperine anti-androgenic hair regrowth testosterone-sensitive black pepper cubeb pepper

Studysummary This study found that Piper nigrum leaf extract showed in vivo anti-androgenic activity and potent 5α-reductase inhibitory effects, with piperine and (−)-cubebin identified as active components.

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