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research Caffeic Acid N-[3,5-Bis(Trifluoromethyl)Phenyl] Amide as a Non-Steroidal Inhibitor for Steroid 5α-Reductase Type 1 Using a Human Keratinocyte Cell-Based Assay and Molecular Dynamics

December 2022 in “Scientific Reports”

Compound 4 is a promising treatment for hair loss with low toxicity.

Natural Product-Inspired Bis(Trifluoromethyl) Phenyl Hydroxycinnamate Derivatives as Promising Nonsteroidal Inhibitors of Human Steroid 5α-Reductase Type-1: Synthesis, In Vitro, and In Silico Studies

research Natural Product-Inspired Bis(Trifluoromethyl) Phenyl Hydroxycinnamate Derivatives as Promising Nonsteroidal Inhibitors of Human Steroid 5α-Reductase Type-1: Synthesis, In Vitro, and In Silico Studies

August 2025 in “ACS Omega”

New compounds show promise as nonsteroidal treatments for hair loss.

research Enzymes

March 2008 in “British Journal of Pharmacology”

Enzymes play crucial roles in metabolism, health, and disease management.

research Enzymes

1 citations , November 2011 in “British journal of pharmacology”

Enzymes are classified into six types and are essential for many biological processes, with only a few targeted by drugs.

research Potential Targets in the Discovery of New Hair Growth Promoters for Androgenic Alopecia

59 citations , May 2014 in “Expert Opinion on Therapeutic Targets”

The document concludes that targeting 5α-reductase, the androgen receptor, and hair growth genes, along with using compounds with anti-androgenic properties, could lead to more effective hair loss treatments.

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community What about this? Topical minoxidil, caffein, melatonin + keto + saw palmetto

in Treatment 1 upvotes 6 months ago

The user plans to treat hair loss with topical minoxidil mixed with caffeine and melatonin, keto shampoo, and oral saw palmetto. They aim to stimulate hair growth, block DHT, and prolong the growth phase without using finasteride or dutasteride.

community 19M - April 2025 vs August 2025 progress

in Progress Pictures 21 upvotes 1 month ago

A 19-year-old shares progress in hair loss treatment from April to August 2025, using oral minoxidil, finasteride, dutasteride, and topical flutamide, minoxidil, dutasteride, and caffeine. The user seeks feedback and suggestions, with encouragement to continue the treatment.

community Suggestions for a good precision scale

in Technology 2 upvotes 1 year ago

The conversation is about finding a precise scale for measuring melatonin. The user needs to add 5mg per 100ml and finds Amazon scales imprecise.

community Should I start with finasteride?

in Finasteride/Dutasteride 15 upvotes 2 years ago

A 28-year-old male is experiencing severe hair loss and is considering finasteride after his doctor prescribed hair growth serum, minoxidil, and Boost solution. Some suggest consulting another doctor for a finasteride prescription, while others share personal success with finasteride.

community What is worth dissolving in topical minoxidil solution?

in Treatment 3 upvotes 1 year ago

Switching from minoxidil foam to topical solution and considering adding caffeine, melatonin, or cetirizine. Currently using 2.5mg oral minoxidil and 1mg oral finasteride, planning to ask for 0.5mg oral dutasteride and 5mg oral minoxidil.

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