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Glossary Mass Spectrometry

measures mass-to-charge ratios of ions in a sample

Mass Spectrometry (MS) is an analytical technique used to measure the mass-to-charge ratio of ions. It helps identify the composition of a sample by generating a spectrum that displays the masses of its components, making it invaluable in fields like chemistry, biology, and medicine for detecting and quantifying molecules, including proteins and metabolites.

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Research

5 / 1000+ results

research Determination Method for Steroid 5α-Reductase Activity Using Liquid Chromatography/Atmospheric Pressure Chemical Ionization–Mass Spectrometry

13 citations , October 2005 in “Analytical Sciences”

This study developed a method using LC/APCI-MS to measure the activity of steroid 5α-reductase, applied to kinetic studies and inhibitory tests with Finasteride in a rat prostatic enzyme model.

research Silver Oxide Based Nanoparticle Assisted Laser Desorption/Ionization Mass Spectrometry for the Detection of Low Molecular Weight Compounds

11 citations , January 2014 in “Mass spectrometry”

In this study, silver oxide-based nanoparticles were used to ionize analytes and detect specific target molecules through adduct formation with silver isotopes, facilitating signal correlation with these molecules.

research How storage post sampling influences the stability of sebum when used for mass spectrometry metabolomics analysis?

7 citations , September 2024 in “Scientific Reports”

This study suggests that sebum samples can be effectively stored and transported with less stringent requirements than liquid samples, making them suitable for remote or at-home collection before clinical analysis.

research A rapid, simple, liquid chromatographic-electrospray ionization, ion trap mass spectrometry method for the determination of finasteride in human plasma and its application to pharmacokinetic study.

5 citations , January 2012 in “PubMed”

This study developed and validated a reliable method using chromatography and mass spectrometry to accurately measure finasteride levels in human plasma.

research Characterization of spironolactone and metabolites derivatized using Girard's reagent P using mass spectrometry and ion mobility spectrometry

4 citations , May 2024 in “Rapid Communications in Mass Spectrometry”

This study demonstrated that GP derivatization improves mass spectral analysis of spironolactone and its metabolites by reducing in-source fragmentation and enhancing signal clarity, laying the groundwork for future advancements in reaction optimization and quantitative assay development.

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Community Join

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community Liquid Chromatography–Mass Spectrometry (LC-MS) VS Enzyme-Linked Immunosorbent Assay (ELISA)

5 upvotes 1 year ago

Finasteride and Nizoral shampoo with Ketoconazole are used for hair loss treatment. Liquid Chromatography–Mass Spectrometry (LC-MS) is recommended over Enzyme-Linked Immunosorbent Assay (ELISA) for more accurate DHT testing.

community Unexpected Serum DHT Elevation after Generic Dutasteride Use.

in Finasteride/Dutasteride 38 upvotes 1 year ago

Switching from finasteride to a generic dutasteride led to unexpectedly high DHT levels, prompting a switch to a reputed brand and consideration of softgel capsules for better absorption. The user plans to retest DHT levels and may return to finasteride if issues persist.

community Interpreting pre-finisteride blood panels

2 upvotes 1 year ago

The conversation is about someone planning to start finasteride for hair loss and wanting to interpret pre-treatment blood panels to assess the risk of side effects like gynecomastia. They list various tests to measure hormone levels and other health indicators.

community Feel like I'm a reasonably good responder

in Is this regrowth? 274 upvotes 2 years ago

The user "OP" reported significant hair regrowth using oral finasteride, oral and topical minoxidil, ketoconazole shampoo, and derma stamping. OP experienced initial shedding but no other side effects.

community Dutasteride SAVES your hair follicles: MAJOR BS on people who say it destroyed their hair permanently.

158 upvotes 2 years ago

The conversation discusses the effectiveness of hair loss treatments, specifically finasteride and dutasteride. The conclusion is that dutasteride significantly reduces DHT levels and may be more effective than finasteride for long-term hair retention, with some users reporting personal experiences and side effects.

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