Comparative Studies on Polyamine Levels in Plasma and Urine of Androgenic Alopecia Patients Treated with Finasteride for a Period of Three Years
January 2020
in “
International Journal of Applied Biology and P
”
New to Finasteride? There is a guide in the encyclopedia. Read the guide → Studysummary This study found that finasteride treatment for androgenic alopecia significantly increased certain plasma polyamine levels over three years, but did not alter polyamine levels in urine. Our plain-language summary of this paper — not a Tressless recommendation.
The study investigated polyamine levels in plasma and urine of 20 androgenic alopecia patients treated with finasteride over three years. Using liquid chromatography-tandem mass spectrometry, it was found that plasma levels of spermidine and N-acetyl spermine significantly increased after two years of treatment, while 1,3-diaminopropane and N-acetyl spermidine levels were significantly higher after three years. However, no significant changes were observed in urine samples. These findings suggested that finasteride treatment altered plasma polyamine concentrations, indicating potential therapeutic effects through polyamine metabolism.
