Comparative Studies on Polyamine Levels in Plasma and Urine of Androgenic Alopecia Patients Treated with Finasteride for a Period of Three Years

The study investigated polyamine levels in plasma and urine of 20 androgenic alopecia patients treated with finasteride over three years. Using liquid chromatography-tandem mass spectrometry, it was found that plasma levels of spermidine and N-acetyl spermine significantly increased after two years of treatment, while 1,3-diaminopropane and N-acetyl spermidine levels were significantly higher after three years. However, no significant changes were observed in urine samples. These findings suggested that finasteride treatment altered plasma polyamine concentrations, indicating potential therapeutic effects through polyamine metabolism.