Finasteride Quantification in Human Plasma by High-Performance Liquid Chromatography Coupled to Electrospray Ionization Tandem Mass Spectrometry: Application to a Comparative Pharmacokinetics Study
April 2015
in “
Drug research
”
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Studysummary This study concluded that two different pharmaceutical formulations of finasteride were bioequivalent in terms of rate and extent of absorption based on pharmacokinetic evaluations in a randomized crossover study with 38 volunteers.
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This document describes a study that developed a method for quantifying finasteride in human plasma using high-performance liquid chromatography coupled to electrospray ionization tandem mass spectrometry. The method was validated for accuracy and precision and found to be stable under various conditions. The method was then used to conduct a comparative pharmacokinetics study of two different formulations of finasteride in 38 volunteers. The study found that the two formulations had similar pharmacokinetic profiles and were bioequivalent.
