Finasteride Quantification in Human Plasma by High-Performance Liquid Chromatography Coupled to Electrospray Ionization Tandem Mass Spectrometry: Application to a Comparative Pharmacokinetics Study

    April 2015 in “ Drug research ”
    R. Moreno, P. Garcia Moreno, Ney Carter do Carmo Borges, J. L. Donato, S. E. Oliveira
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    TLDR New method measures finasteride in plasma, finds two formulations bioequivalent.
    This document describes a study that developed a method for quantifying finasteride in human plasma using high-performance liquid chromatography coupled to electrospray ionization tandem mass spectrometry. The method was validated for accuracy and precision and found to be stable under various conditions. The method was then used to conduct a comparative pharmacokinetics study of two different formulations of finasteride in 38 volunteers. The study found that the two formulations had similar pharmacokinetic profiles and were bioequivalent.
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