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GlossaryBioequivalence

...similarity in drug absorption and effect between two formulations

Bioequivalence refers to the relationship between two drugs that have the same active ingredients and are expected to have the same effect on the body. For two drugs to be considered bioequivalent, they must show similar bioavailability, meaning they release their active ingredients into the bloodstream at the same rate and extent. This concept is crucial for approving generic drugs, ensuring they perform just as effectively as their brand-name counterparts.

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Formulation of a Film-Coated Dutasteride Tablet Bioequivalent to a Soft Gelatin Capsule (Avodart): Effect of Gamma-Cyclodextrin and Solubilizers

research Formulation of a Film-Coated Dutasteride Tablet Bioequivalent to a Soft Gelatin Capsule (Avodart): Effect of Gamma-Cyclodextrin and Solubilizers

4 citations, May 2019 in “Asian Journal of Pharmaceutical Sciences”

Created tablet similar to Avodart using γ-cyclodextrin and solubilizers.

Finasteride Quantification in Human Plasma by High-Performance Liquid Chromatography Coupled to Electrospray Ionization Tandem Mass Spectrometry: Application to a Comparative Pharmacokinetics Study

research Finasteride Quantification in Human Plasma by High-Performance Liquid Chromatography Coupled to Electrospray Ionization Tandem Mass Spectrometry: Application to a Comparative Pharmacokinetics Study

1 citations, April 2015 in “Drug research”

New method measures finasteride in plasma, finds two formulations bioequivalent.

Bioequivalence of a Single 10-mg Dose of Finasteride 5-mg Oral Disintegrating Tablets and Standard Tablets in Healthy Adult Male Han Chinese Volunteers: A Randomized Sequence, Open-Label, Two-Way Crossover Study

research Bioequivalence of a Single 10-mg Dose of Finasteride 5-mg Oral Disintegrating Tablets and Standard Tablets in Healthy Adult Male Han Chinese Volunteers: A Randomized Sequence, Open-Label, Two-Way Crossover Study

10 citations, October 2009 in “Clinical Therapeutics”

Finasteride 5-mg oral disintegrating tablets and standard tablets are bioequivalent in healthy adult male Han Chinese volunteers.

Original Research—Endocrinology: Comparison of the Steady-State Pharmacokinetics, Metabolism, and Variability of a Transdermal Testosterone Patch Versus a Transdermal Testosterone Gel in Hypogonadal Men

research Original Research—Endocrinology: Comparison of the Steady-State Pharmacokinetics, Metabolism, and Variability of a Transdermal Testosterone Patch Versus a Transdermal Testosterone Gel in Hypogonadal Men

38 citations, February 2005 in “The journal of sexual medicine”

The testosterone patch and gel are both effective, but they have different absorption patterns and effects on hormone levels.

Evaluation of Bioequivalence of Five 0.1 mg Dutasteride Capsules Compared to One 0.5 mg Dutasteride Capsule: A Randomized Study in Healthy Male Volunteers

research Evaluation of Bioequivalence of Five 0.1 mg Dutasteride Capsules Compared to One 0.5 mg Dutasteride Capsule: A Randomized Study in Healthy Male Volunteers

3 citations, January 2015 in “Journal of drug assessment”

Taking five small dutasteride capsules is the same as taking one larger capsule.

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community Reminder: you can get dutasteride for $6.33 / month in the United States

in Finasteride/Dutasteride 67 upvotes 1 month ago

Dutasteride can be obtained for $6.33 per month in the US through Cost Plus Drugs, with prescriptions easily switched from finasteride by contacting a doctor. Users discuss various methods to obtain affordable dutasteride, including using online pharmacies and considering generic options, while cautioning against buying from unreliable sources like eBay.