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GlossaryBiotransformation

process of chemically altering substances in the body

Biotransformation is the process by which the body chemically alters substances, such as drugs or toxins, to make them easier to eliminate. This typically occurs in the liver and involves enzymatic reactions that convert these substances into more water-soluble compounds, facilitating their excretion through urine or bile.

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research The Human Gut Chemical Landscape Predicts Microbe-Mediated Biotransformation of Foods and Drugs

36 citations , June 2019 in “eLife”

The study developed a tool to predict how gut microbes process foods and drugs, showing that similar compounds often share metabolic pathways and effects.

research Metabolism of Minoxidil, a New Hypotensive Agent: Biotransformation Following Oral Administration to Rats, Dogs, and Monkeys

31 citations , August 1975 in “Journal of Pharmaceutical Sciences”

Minoxidil metabolizes similarly in monkeys and humans, but differently in dogs and rats.

Biotransformation of Finasteride by Ocimum Sanctum L., and Tyrosinase Inhibitory Activity of Transformed Metabolites: Experimental and Computational Insights

research Biotransformation of Finasteride by Ocimum Sanctum L., and Tyrosinase Inhibitory Activity of Transformed Metabolites: Experimental and Computational Insights

3 citations , December 2014 in “Steroids”

Fermentation of Finasteride with Ocimum sanctum L. creates new metabolite that inhibits tyrosinase.

research Biotransformation of Tirilazad in Humans: Effect of Finasteride on Tirilazad Clearance and Reduced Metabolite Formation

3 citations , November 1998 in “PubMed”

research Biotransformation of Finasteride (MK-0906) by Selenastrum Capricornutum (Green Algae)

1 citations , December 2006 in “Annals of the New York Academy of Sciences”

Green algae can break down finasteride, reducing environmental harm.

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